PIP5K1B
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Protein Summary
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
- ENST00000265382
- ENSP00000265382
- ENSG00000107242
- ENST00000478500
- ENSP00000435778
- ENST00000541509
- ENSP00000438082
- STM7
- MSS4
- STM7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
drug perturbation | 0.87 | ||
transcription factor perturbation | 0.84 | ||
histone modification site profile | 0.79 | ||
transcription factor binding site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.91 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 137 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.91 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 137 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0