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Tbio
PIP5K1B
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Protein Summary
Description
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265382
  • ENSP00000265382
  • ENSG00000107242
  • ENST00000478500
  • ENSP00000435778
  • ENST00000541509
  • ENSP00000438082

Symbol
  • STM7
  • MSS4
  • STM7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
drug perturbation
0.87
transcription factor perturbation
0.84
histone modification site profile
0.79
transcription factor binding site profile
0.78


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.98   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.98   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
4
7
11.6
94.3
creatinine measurement
4
3
4
85.2
fibroblast growth factor 23 measurement
1
1
1
49.5
1
1
0
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
11.6
94.3
creatinine measurement
4
85.2
fibroblast growth factor 23 measurement
1
49.5
0
1
13.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
VGNC:10056
464513
Macaque
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
700538
Mouse
MGI:107930
18719
Rat
RGD:1310914
309419
Dog
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
VGNC:44575
476331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Macaque
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Mouse
Rat
Dog
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14986-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (35)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Negative regulation of the PI3K/AKT network
Reactome
PI Metabolism
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
Metabolism
Metabolism of lipids
Negative regulation of the PI3K/AKT network
PI Metabolism
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
PIK3CD
Tclin
Family: Kinase
Novelty: 0.00572779
Score: 0.969
Data Source: STRINGDB
TLN1
Tbio
Novelty: 0.00803981
Score: 0.966
Data Source: STRINGDB
PI4KB
Tchem
Family: Kinase
Novelty: 0.00856875
Score: 0.963
Data Source: STRINGDB
PI4KA
Tchem
Family: Kinase
Novelty: 0.01701469
Score: 0.958
Data Source: STRINGDB
PIK3CB
Tchem
Family: Kinase
Novelty: 0.00390277
Score: 0.955
Data Source: STRINGDB
SACM1L
Tbio
Family: Enzyme
Novelty: 0.00499867
Score: 0.949
Data Source: STRINGDB
PLCD1
Tchem
Family: Enzyme
Novelty: 0.00742197
Score: 0.936
Data Source: STRINGDB
PIK3CG
Tclin
Family: Kinase
Novelty: 0.00170533
Score: 0.936
Data Source: STRINGDB
PI4K2A
Tbio
Family: Kinase
Novelty: 0.03506675
Score: 0.935
Data Source: STRINGDB
PLCE1
Tbio
Family: Enzyme
Novelty: 0.0070258
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.98

PubMed score by year
PubTator Score  16.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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