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Tchem
ATP2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Protein Summary
Description
Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357084
  • ENSP00000349595
  • ENSG00000196296
  • ENST00000395503
  • ENSP00000378879
  • ENST00000536376
  • ENSP00000443101

Symbol
  • ATP2A
  • SERCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
gene perturbation
0.69
cellular component
0.67
biological process
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.24   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.24   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
94.3
waist-hip ratio
1
1
1
89
testosterone measurement
1
1
1
87
2
2
1
1
80.8
lifestyle measurement
1
1
1
71.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
94.3
waist-hip ratio
1
89
testosterone measurement
1
87
1
1
80.8
lifestyle measurement
1
71.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
VGNC:9020
454019
Mouse
MGI:105058
11937
Dog
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
VGNC:38253
479797
Horse
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
VGNC:15650
100064403
Cow
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
VGNC:26290
518117
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Mouse
Dog
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Horse
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Cow
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Pathways (33)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Gene Ontology Terms (35)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (144)
1 – 10 of 144
LRRCC1
Tdark
Novelty: 0.14730953
p_int: 0.999837991
p_ni: 0.000162009
Score: 0.231
Data Source: BioPlex,STRINGDB
GCNT2
Tbio
Family: Enzyme
Novelty: 0.03945461
p_int: 0.999249383
p_ni: 0.000750617
Score: 0.219
Data Source: BioPlex,STRINGDB
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.998658314
p_ni: 0.001341686
Data Source: BioPlex
VNN2
Tbio
Novelty: 0.02286648
p_int: 0.997378661
p_ni: 0.002621339
Score: 0.166
Data Source: BioPlex,STRINGDB
ROGDI
Tbio
Novelty: 0.077277
p_int: 0.997114029
p_ni: 0.002885971
Score: 0.219
Data Source: BioPlex,STRINGDB
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00609294
p_int: 0.995863961
p_ni: 0.004136039
Score: 0.349
Data Source: BioPlex,STRINGDB
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.988064184
p_ni: 0.011935816
Data Source: BioPlex
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.980534577
p_ni: 0.019465423
Data Source: BioPlex
TLE3
Tbio
Novelty: 0.02641884
p_int: 0.974610859
p_ni: 0.02538914
p_wrong: 1e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.97022078
p_ni: 0.02977922
Data Source: BioPlex
Publication Statistics
PubMed Score  272.24

PubMed score by year
PubTator Score  117.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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