Tchem ATP2A1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Protein Summary

Description

Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• O14983
• A8K5J9
• B3KY17
• O14984
• SERCA1

Gene Name

• ATP2A1

Ensembl ID

• ENST00000357084
• ENSP00000349595
• ENSG00000196296
• ENST00000395503
• ENSP00000378879
• ENST00000536376
• ENSP00000443101

Symbol

• ATP2A
• SERCA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	1
gene perturbation	0.69
cellular component	0.67
biological process	0.66

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Sarcoplasmic/endoplasmic Reticulum Calcium Atpase 1

Protein / Transporter / Cation Transporter / Sarcoplasmic/endoplasmic Reticulum Calcium Atpase 1

Protein / Hydrolase / Sarcoplasmic/endoplasmic Reticulum Calcium Atpase 1

DTO Classes

Protein / Transporter / P-type Atpases / Ca2+-atpases / Sarcoplasmic/endoplasmic Reticulum Calcium Atpase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.9   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.9   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0