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Tclin
XPO1
Exportin-1

Protein Classes
Protein Summary
Description
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus fro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401558
  • ENSP00000384863
  • ENSG00000082898
  • ENST00000404992
  • ENSP00000385942
  • ENST00000406957
  • ENSP00000385559

Symbol
  • CRM1
  • emb
  • CRM1
  • exp1
  • CRM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
1
transcription factor binding site profile
0.95
transcription factor perturbation
0.91
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1278.57   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1278.57   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
selinexor
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
84.9
eosinophil count
3
2
3
68.3
1
2
0
1.1
53.1
mean reticulocyte volume
1
1
1
49.6
leukocyte count
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
84.9
eosinophil count
3
68.3
0
1.1
53.1
mean reticulocyte volume
1
49.6
leukocyte count
1
47.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exportin 1
VGNC:477
459534
Macaque
exportin 1
718063
Mouse
MGI:2144013
103573
Rat
RGD:620517
85252
Dog
exportin 1
VGNC:48460
474609
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exportin 1
Macaque
exportin 1
Mouse
Rat
Dog
exportin 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14980-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (62)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (37)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (528)
1 – 10 of 528
LPAR4
Tchem
Family: GPCR
Novelty: 0.02200758
p_int: 0.865020057
p_ni: 0.134979943
Score: 0.187
Data Source: BioPlex,STRINGDB
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.781738634
p_ni: 0.218261366
Score: 0.185
Data Source: BioPlex,STRINGDB
RAN
Tbio
Family: Enzyme
Novelty: 0.00160888
Score: 0.999
Data Source: Reactome,STRINGDB
RANGAP1
Tbio
Family: Enzyme
Novelty: 0.00917672
Score: 0.997
Data Source: STRINGDB
NUP214
Tbio
Novelty: 0.00924336
Score: 0.992
Data Source: STRINGDB
SNUPN
Tbio
Novelty: 0.04456914
Score: 0.992
Data Source: STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00484823
Score: 0.991
Data Source: STRINGDB
NUP153
Tbio
Novelty: 0.00696568
Score: 0.984
Data Source: STRINGDB
NUP62
Tbio
Novelty: 0.01432724
Score: 0.983
Data Source: STRINGDB
ANP32A
Tbio
Novelty: 0.00567095
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  1278.57

PubMed score by year
PubTator Score  824.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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