Tchem GAK Cyclin-G-associated kinase

Protein Summary

Description

Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• O14976
• Q5U4P5
• Q9BVY6

Gene Name

• GAK

Ensembl ID

• ENST00000314167
• ENSP00000314499
• ENSG00000178950
• ENST00000511163
• ENSP00000421361

Symbol

• DNAJ26
• DNAJC26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule	1
protein domain	0.97
drug perturbation	0.96
disease perturbation	0.95
molecular function	0.91

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-g-associated Kinase

Protein / Chaperone / Cyclin-g-associated Kinase

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Nak Family / Cyclin-g-associated Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.24   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 293   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.24   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 56

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7