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Tchem
GAK
Cyclin-G-associated kinase

Protein Summary
Description
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314167
  • ENSP00000314499
  • ENSG00000178950
  • ENST00000511163
  • ENSP00000421361

Symbol
  • DNAJ26
  • DNAJC26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
1
protein domain
0.97
drug perturbation
0.96
disease perturbation
0.95
molecular function
0.91


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.97   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.97   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
93.2
triglyceride measurement
1
1
1
41.5
high density lipoprotein cholesterol measurement
1
1
1
18.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
93.2
triglyceride measurement
1
41.5
high density lipoprotein cholesterol measurement
1
18.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin G associated kinase
VGNC:2987
461048
Macaque
cyclin G associated kinase
703406
Mouse
MGI:2442153
231580
Rat
RGD:621589
81659
Dog
cyclin G associated kinase
VGNC:41074
479133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin G associated kinase
Macaque
cyclin G associated kinase
Mouse
Rat
Dog
cyclin G associated kinase
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14976-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (345)
1 – 10 of 345
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.999989347
p_ni: 0.000010652
Score: 0.595
Data Source: BioPlex,STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
p_int: 0.999968788
p_ni: 0.000031212
Data Source: BioPlex
DAPP1
Tbio
Novelty: 0.05145215
p_int: 0.999636866
p_ni: 0.000363133
p_wrong: 2e-9
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.999445901
p_ni: 0.000554097
p_wrong: 2e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.99942816
p_ni: 0.000571839
p_wrong: 1e-9
Score: 0.381
Data Source: BioPlex,STRINGDB
S100A4
Tbio
Novelty: 0.00136919
p_int: 0.99894398
p_ni: 0.001056016
p_wrong: 4e-9
Data Source: BioPlex
RABGEF1
Tbio
Novelty: 0.02830695
p_int: 0.995729417
p_ni: 0.00427058
p_wrong: 3e-9
Score: 0.527
Data Source: BioPlex,STRINGDB
HSPBP1
Tbio
Novelty: 0.01176285
p_int: 0.99331541
p_ni: 0.00668459
Score: 0.158
Data Source: BioPlex,STRINGDB
DMWD
Tbio
Novelty: 0.04096001
p_int: 0.99301929
p_ni: 0.00698071
Score: 0.432
Data Source: BioPlex,STRINGDB
HIP1R
Tbio
Novelty: 0.02502713
p_int: 0.969561543
p_ni: 0.030429769
p_wrong: 0.000008688
Score: 0.993
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  126.97

PubMed score by year
PubTator Score  42.02

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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