Tbio SLC27A2 Very long-chain acyl-CoA synthetase

Protein Summary

Description

Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity). The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• O14975
• A8K2J7
• Q53FY6
• Q6PF09
• VLACS

Gene Name

• SLC27A2

Ensembl ID

• ENST00000267842
• ENSP00000267842
• ENSG00000140284
• ENST00000380902
• ENSP00000370289

Symbol

• ACSVL1
• FACVL1
• FATP2
• VLACS
• VLCS
• FATP2
• VLACS
• ACSVL1
• FACVL1
• hFACVL1
• HsT17226

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
gene perturbation	0.98
molecular function	0.98
PubMedID	0.95
histone modification site profile	0.8

Protein Classes

PANTHER Classes

Protein / Ligase / Very Long-chain Acyl-coa Synthetase

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc27 Family Of Fatty Acid Transporters / Very Long-chain Acyl-coa Synthetase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.55   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.55   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (219)

Explore Interacting Targets

1 – 10 of 219

• See Interactions on String-DB

SCGB2A1

Tbio

Novelty:  0.01902973

p_int:  0.999926282

p_ni:  0.000073718

Data Source:  BioPlex

RANBP6

Tdark

Novelty:  0.75714796

p_int:  0.999706887

p_ni:  0.000293113

Data Source:  BioPlex

PPP6R2

Tbio

Family:  Enzyme

Novelty:  0.12886225

p_int:  0.999681588

p_ni:  0.000318412

Data Source:  BioPlex

HAUS7

Tbio

Novelty:  1.11657571

p_int:  0.998749533

p_ni:  0.001250467

Data Source:  BioPlex

SCGB2A2

Tbio

Novelty:  0.01594053

p_int:  0.997246466

p_ni:  0.002753534

Data Source:  BioPlex

ARMC6

Tdark

Novelty:  0.58706267

p_int:  0.996703591

p_ni:  0.003296409

Data Source:  BioPlex

MINDY2

Tbio

Novelty:  0.46783751

p_int:  0.992228593

p_ni:  0.007771407

Data Source:  BioPlex

FAM177A1

Tdark

Novelty:  0.31314275

p_int:  0.991186157

p_ni:  0.008813843

Data Source:  BioPlex

BCL2L2

Tchem

Novelty:  0.00430896

p_int:  0.984597891

p_ni:  0.015402109

Score:  0.18

Data Source:  BioPlex,STRINGDB

PNPLA3

Tbio

Family:  Enzyme

Novelty:  0.00180327

p_int:  0.964647678

p_ni:  0.035352322

Score:  0.464

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (25)

Reactome (15)

KEGG (3)

PathwayCommons (4)

WikiPathways (3)

Alpha-oxidation of phytanate (R-HSA-389599)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Alpha-oxidation of phytanate	6 targets	R-HSA-389599
Reactome	Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Reactome	Fatty acid metabolism	176 targets	R-HSA-8978868
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Alpha-oxidation of phytanate	6 targets	R-HSA-389599
Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Fatty acid metabolism	176 targets	R-HSA-8978868
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (10)

Components (10)

Processes (9)

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1 – 10 of 10

GO Term	Evidence	Assigned by
long-chain fatty acid-CoA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
phytanate-CoA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
pristanate-CoA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
very long-chain fatty acid-CoA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
signaling receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
fatty acid transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
long-chain fatty acid transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
decanoate-CoA ligase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
basophil count	EFO_0005090	3	2	3		83.2
blood metabolite measurement	EFO_0005664	1	1	1		60.5
platelet count	EFO_0004309	1	1	1		53.7
FEV/FEC ratio	EFO_0004713	1	1	1		31.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
basophil count	EFO_0005090	3		83.2
blood metabolite measurement	EFO_0005664	1		60.5
platelet count	EFO_0004309	1		53.7
FEV/FEC ratio	EFO_0004713	1		31.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
ATP-binding
Complete proteome
Endoplasmic reticulum
Fatty acid metabolism
Ligase
Lipid metabolism
Membrane
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
basophil count
blood metabolite measurement
FEV/FEC ratio
platelet count

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 27 member 2	VGNC:7775	453423
Macaque	solute carrier family 27 member 2		715237
Mouse	solute carrier family 27 (fatty acid transporter), member 2	MGI:1347099	26458
Rat	solute carrier family 27 member 2	RGD:71103	65192
Dog	solute carrier family 27 member 2	VGNC:46330	478298

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 27 member 2
Macaque	solute carrier family 27 member 2
Mouse	solute carrier family 27 (fatty acid transporter), member 2
Rat	solute carrier family 27 member 2
Dog	solute carrier family 27 member 2

Publication Statistics

PubMed Score 71.55

PubMed score by year

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PubTator Score 33.40

PubTator score by year

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Related Publications

Text Mined References (28)

GeneRif Annotations (8)

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PMID	Year	Title