Tbio SLC27A2 Very long-chain acyl-CoA synthetase

Protein Summary

Description

Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity). The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• O14975
• A8K2J7
• Q53FY6
• Q6PF09
• VLACS

Gene Name

• SLC27A2

Ensembl ID

• ENST00000267842
• ENSP00000267842
• ENSG00000140284
• ENST00000380902
• ENSP00000370289

Symbol

• ACSVL1
• FACVL1
• FATP2
• VLACS
• VLCS
• FATP2
• VLACS
• ACSVL1
• FACVL1
• hFACVL1
• HsT17226

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
gene perturbation	0.98
molecular function	0.98
PubMedID	0.95
histone modification site profile	0.8

Protein Classes

PANTHER Classes

Protein / Ligase / Very Long-chain Acyl-coa Synthetase

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc27 Family Of Fatty Acid Transporters / Very Long-chain Acyl-coa Synthetase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.4   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.4   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0