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Tbio
PPP1R12A
Protein phosphatase 1 regulatory subunit 12A

Protein Summary
Description
Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261207
  • ENSP00000261207
  • ENSG00000058272
  • ENST00000437004
  • ENSP00000416769
  • ENST00000450142
  • ENSP00000389168
  • ENST00000546369
  • ENSP00000449514
  • ENST00000550107
  • ENSP00000446855

Symbol
  • MBS
  • MYPT1
  • MBS
  • M130
  • MYPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
hub protein
0.9
kinase
0.9
cellular component
0.88
interacting protein
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.82   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 558   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.82   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 558   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
14.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
14.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 12A
VGNC:5542
452095
Macaque
protein phosphatase 1 regulatory subunit 12A
695735
Mouse
MGI:1309528
17931
Rat
RGD:620013
116670
Dog
protein phosphatase 1 regulatory subunit 12A
VGNC:44878
475411
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 12A
Macaque
protein phosphatase 1 regulatory subunit 12A
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 12A
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G2/M Transition
Reactome
Mitotic G2-G2/M phases
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G2/M Transition
Mitotic G2-G2/M phases
RHO GTPase Effectors
Protein-Protein Interactions (189)
1 – 10 of 189
PHF7
Tbio
Family: Epigenetic
Novelty: 0.0925472
p_int: 0.999966986
p_ni: 0.000033014
Score: 0.269
Data Source: BioPlex,STRINGDB
FKBP6
Tbio
Family: Enzyme
Novelty: 0.02240256
p_int: 0.999966025
p_ni: 0.000033975
Score: 0.192
Data Source: BioPlex,STRINGDB
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 0.999965487
p_ni: 0.000034513
Data Source: BioPlex
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.999960821
p_ni: 0.000039179
Data Source: BioPlex
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
p_int: 0.999937003
p_ni: 0.000061753
p_wrong: 0.000001244
Data Source: BioPlex
NUAK2
Tchem
Family: Kinase
Novelty: 0.02463599
p_int: 0.999711861
p_ni: 0.000288139
Score: 0.746
Data Source: BioPlex,STRINGDB
SH3BP5L
Tdark
Novelty: 1.7921497
p_int: 0.999479896
p_ni: 0.000520103
p_wrong: 1e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
THRSP
Tbio
Novelty: 0.00938864
p_int: 0.998952394
p_ni: 0.000802192
p_wrong: 0.000245414
Data Source: BioPlex
ZNF263
Tbio
Family: TF
Novelty: 0.098799
p_int: 0.998206999
p_ni: 0.00179091
p_wrong: 0.000002092
Score: 0.196
Data Source: BioPlex,STRINGDB
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.998060666
p_ni: 0.001938439
p_wrong: 8.96e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  338.82

PubMed score by year
PubTator Score  151.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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