RAB29
Ras-related protein Rab-7L1
Protein Summary
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
- ENST00000235932
- ENSP00000235932
- ENSG00000117280
- ENST00000367139
- ENSP00000356107
- ENST00000414729
- ENSP00000402910
- ENST00000437324
- ENSP00000416613
- ENST00000446390
- ENSP00000389899
- RAB7L1
- RAB7L
- RAB7L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
cellular component | 0.79 | ||
PubMedID | 0.78 | ||
tissue sample | 0.71 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.32 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 147 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.32 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 147 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0