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Tbio
HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

Protein Summary
Description
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329138
  • ENSP00000331201
  • ENSG00000185359

Symbol
  • HRS
  • HRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
hub protein
0.96
interacting protein
0.96
disease perturbation
0.93
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.28   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 497   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.28   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (58)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Deubiquitination
Reactome
Disease
Reactome
EGFR downregulation
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Deubiquitination
Disease
EGFR downregulation
Protein-Protein Interactions (297)
1 – 10 of 297
STAM
Tbio
Novelty: 0.0332731
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999771252
p_ni: 0.000228748
Score: 0.181
Data Source: BioPlex,STRINGDB
HSPBP1
Tbio
Novelty: 0.01176285
p_int: 0.963011799
p_ni: 0.035866521
p_wrong: 0.00112168
Score: 0.191
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.915517514
p_ni: 0.045635035
p_wrong: 0.038847451
Data Source: BioPlex
TSG101
Tbio
Novelty: 0.00211746
Score: 0.998
Data Source: Reactome,STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.991
Data Source: Reactome,STRINGDB
STAM2
Tbio
Novelty: 0.04440236
Score: 0.991
Data Source: Reactome,STRINGDB
CLTC
Tbio
Novelty: 0.00256674
Score: 0.99
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.99
Data Source: STRINGDB
VPS36
Tbio
Novelty: 0.03382542
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  125.28

PubMed score by year
PubTator Score  51.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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