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Tbio
HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

Protein Summary
Description
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329138
  • ENSP00000331201
  • ENSG00000185359

Symbol
  • HRS
  • HRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
hub protein
0.96
interacting protein
0.96
disease perturbation
0.93
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.3   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 497   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.3   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (297)
1 – 10 of 297
STAM
Tbio
Novelty:  0.0332731
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999771252
p_ni:  0.000228748
Score:  0.181
Data Source:  BioPlex,STRINGDB
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.963011799
p_ni:  0.035866521
p_wrong:  0.00112168
Score:  0.191
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.915517514
p_ni:  0.045635035
p_wrong:  0.038847451
Data Source:  BioPlex
TSG101
Tbio
Novelty:  0.00211746
Score:  0.998
Data Source:  Reactome,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.991
Data Source:  Reactome,STRINGDB
STAM2
Tbio
Novelty:  0.04440236
Score:  0.991
Data Source:  Reactome,STRINGDB
CLTC
Tbio
Novelty:  0.00256674
Score:  0.99
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.99
Data Source:  STRINGDB
VPS36
Tbio
Novelty:  0.03382542
Score:  0.988
Data Source:  STRINGDB
Pathways (58)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Deubiquitination
Reactome
Disease
Reactome
EGFR downregulation
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Deubiquitination
Disease
EGFR downregulation
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
3
0
1.1
96.9
Myopia
3
3
0
1.2
86.3
ganglion cell inner plexiform layer thickness measurement
1
1
1
79.5
optic disc size measurement
1
1
1
76.8
intraocular pressure measurement
1
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
96.9
Myopia
0
1.2
86.3
ganglion cell inner plexiform layer thickness measurement
1
79.5
optic disc size measurement
1
76.8
intraocular pressure measurement
2
70.4
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hepatocyte growth factor-regulated tyrosine kinase substrate
454966
Macaque
hepatocyte growth factor-regulated tyrosine kinase substrate
714385
Mouse
MGI:104681
15239
Rat
RGD:69225
56084
Dog
hepatocyte growth factor-regulated tyrosine kinase substrate
VGNC:41677
483367
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hepatocyte growth factor-regulated tyrosine kinase substrate
Macaque
hepatocyte growth factor-regulated tyrosine kinase substrate
Mouse
Rat
Dog
hepatocyte growth factor-regulated tyrosine kinase substrate
Publication Statistics
PubMed Score 127.30
PubMed score by year
PubTator Score 51.54
PubTator score by year