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Tbio
LECT2
Leukocyte cell-derived chemotaxin-2

Protein Summary
Description
Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921). This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274507
  • ENSP00000274507
  • ENSG00000145826

Symbol
  • chm2
  • chm-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
gene perturbation
0.74
biological term
0.43
protein domain
0.41
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.01   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.01   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (18)
1 – 10 of 18
CNMD
Tbio
Novelty: 0.00863815
Score: 0.804
Data Source: STRINGDB
LYZ
Tbio
Family: Enzyme
Novelty: 0.00100348
Score: 0.57
Data Source: STRINGDB
CTSK
Tchem
Family: Enzyme
Novelty: 0.00091225
Score: 0.556
Data Source: STRINGDB
SACS
Tbio
Novelty: 0.00171216
Score: 0.544
Data Source: STRINGDB
SVIL
Tbio
Novelty: 0.04474735
Score: 0.544
Data Source: STRINGDB
FGG
Tbio
Novelty: 0.00622014
Score: 0.538
Data Source: STRINGDB
KLHDC4
Tdark
Novelty: 3
Score: 0.509
Data Source: STRINGDB
SELENOP
Tbio
Novelty: 0.00258768
Score: 0.508
Data Source: STRINGDB
CEBPA
Tbio
Family: TF
Novelty: 0.00103676
Score: 0.499
Data Source: STRINGDB
CDC37L1
Tbio
Novelty: 0.07264148
Score: 0.494
Data Source: STRINGDB
Publication Statistics
PubMed Score  93.01

PubMed score by year
PubTator Score  60.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer