Tbio LECT2 Leukocyte cell-derived chemotaxin-2

Protein Summary

Description

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921). This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14960
• B2RA90
• O14565
• Q52M49
• LECT-2

Gene Name

• LECT2

Ensembl ID

• ENST00000274507
• ENSP00000274507
• ENSG00000145826

Symbol

• chm2
• chm-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
gene perturbation	0.74
biological term	0.43
protein domain	0.41
protein complex	0.4

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / Leukocyte Cell-derived Chemotaxin-2

DTO Classes

Protein / Signaling / Chemokine / Leukocyte Cell-derived Chemotaxin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.28   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 258   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.28   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0