Tbio UQCR11 Cytochrome b-c1 complex subunit 10

Protein Summary

Description

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor. This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• O14957
• B2R542
• D6W5Z4
• Q9UEA3
• Q9UPK4

Gene Name

• UQCR11

Ensembl ID

• ENST00000585671
• ENSP00000466420
• ENSG00000127540
• ENST00000589880
• ENSP00000467555
• ENST00000591899
• ENSP00000467262

Symbol

• UQCR
• UQCR
• QCR10
• 0710008D09Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
kinase perturbation	0.91
histone modification site profile	0.84
cell type or tissue	0.81
virus perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0