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Tbio
MYL12B
Myosin regulatory light chain 12B

Protein Summary
Description
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237500
  • ENSP00000237500
  • ENSG00000118680
  • ENST00000400175
  • ENSP00000383037
  • ENST00000581193
  • ENSP00000463559
  • ENST00000584539
  • ENSP00000464464
  • ENST00000648965
  • ENSP00000496809

Symbol
  • MRLC2
  • MYLC2B
  • MLC-B
  • MRLC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.95
hub protein
0.88
cell type or tissue
0.82
cellular component
0.81


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.76   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.76   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 12B
VGNC:5190
455313
Mouse
MGI:107494
67938
Rat
RGD:628855
50685
Dog
myosin light chain 12B
VGNC:53622
480193
Horse
myosin regulatory light polypeptide 9
100051370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 12B
Mouse
Rat
Dog
myosin light chain 12B
Horse
myosin regulatory light polypeptide 9
Pathways (25)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHA-mediated growth cone collapse
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
Muscle contraction
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (150)
1 – 10 of 150
MYO18A
Tbio
Novelty: 0.05058328
p_int: 0.999999914
p_ni: 8.6e-8
Score: 0.403
Data Source: BioPlex,STRINGDB
MYO3A
Tbio
Family: Kinase
Novelty: 0.0364819
p_int: 0.999999914
p_ni: 3.1e-8
p_wrong: 5.5e-8
Score: 0.285
Data Source: BioPlex,STRINGDB
UBE3B
Tbio
Family: Enzyme
Novelty: 0.06274049
p_int: 0.99999834
p_ni: 0.000001658
p_wrong: 1e-9
Data Source: BioPlex
EFCAB7
Tdark
Novelty: 0.36952617
p_int: 0.999998136
p_ni: 0.000001737
p_wrong: 1.28e-7
Data Source: BioPlex
IQCE
Tdark
Novelty: 0.24800472
p_int: 0.999994362
p_ni: 0.000003014
p_wrong: 0.000002624
Data Source: BioPlex
IQGAP1
Tbio
Family: Enzyme
Novelty: 0.00434481
p_int: 0.999938501
p_ni: 0.000061499
Score: 0.324
Data Source: BioPlex,STRINGDB
MYH14
Tbio
Novelty: 0.00874871
p_int: 0.999919198
p_ni: 0.000080802
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
MYO19
Tbio
Novelty: 0.13070371
p_int: 0.999811518
p_ni: 0.000188482
Score: 0.251
Data Source: BioPlex,STRINGDB
MYH10
Tbio
Novelty: 0.00624251
p_int: 0.999788869
p_ni: 0.000211132
Score: 0.983
Data Source: BioPlex,Reactome,STRINGDB
MYO5A
Tbio
Novelty: 0.00373224
p_int: 0.996847475
p_ni: 0.003152525
Score: 0.207
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  83.76

PubMed score by year
PubTator Score  49.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer