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Tbio
TFEC
Transcription factor EC

Protein Summary
Description
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265440
  • ENSP00000265440
  • ENSG00000105967
  • ENST00000320239
  • ENSP00000318676
  • ENST00000393485
  • ENSP00000377125
  • ENST00000457268
  • ENSP00000387650

Symbol
  • BHLHE34
  • TCFEC
  • TFECL
  • TCFEC
  • TFE-C
  • TFECL
  • TFEC-L
  • bHLHe34
  • hTFEC-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
PubMedID
0.87
microRNA
0.83
transcription factor perturbation
0.74
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.26   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.26   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
TFEB
Tbio
Family:  TF
Novelty:  0.00248413
p_int:  0.999999973
p_wrong:  2.6e-8
Score:  0.664
Data Source:  BioPlex,STRINGDB
CSF2RB
Tclin
Novelty:  0.02093804
Score:  0.706
Data Source:  STRINGDB
FBXW5
Tbio
Novelty:  0.13100873
Score:  0.666
Data Source:  STRINGDB
CSF3R
Tclin
Novelty:  0.00416485
Score:  0.651
Data Source:  STRINGDB
CTSK
Tchem
Family:  Enzyme
Novelty:  0.0007707
Score:  0.639
Data Source:  STRINGDB
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.637
Data Source:  STRINGDB
LY86
Tbio
Novelty:  0.00314575
Score:  0.636
Data Source:  STRINGDB
TRIOBP
Tbio
Novelty:  0.04145641
Score:  0.623
Data Source:  STRINGDB
CEBPE
Tbio
Family:  TF
Novelty:  0.01183291
Score:  0.621
Data Source:  STRINGDB
STAB1
Tbio
Novelty:  0.01303265
Score:  0.614
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
4
5
89.3
platelet crit
1
1
1
39.6
chronotype measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
89.3
platelet crit
1
39.6
chronotype measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1333760
21426
Rat
RGD:3846
26296
Dog
transcription factor EC
VGNC:47295
100856330
Horse
transcription factor EC
VGNC:24040
100055933
Cow
transcription factor EC
VGNC:35789
539016
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transcription factor EC
Horse
transcription factor EC
Cow
transcription factor EC
Publication Statistics
PubMed Score 23.26
PubMed score by year
PubTator Score 10.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title