Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

Gene Name

EREG

Ensembl ID

ENST00000244869
ENSP00000244869
ENSG00000124882

Symbol

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1

gene perturbation	0.98

PubMedID	0.77

microRNA	0.7

histone modification site profile	0.68

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.93 (req: < 5)

View Publications

Gene RIFs: 42 (req: <= 3)

View Gene RIFs

Antibodies: 260 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.93 (req: >= 5)

Gene RIFs: 42 (req: > 3)

Antibodies: 260 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	epiregulin	VGNC:10858	740028

Mouse	epiregulin	MGI:107508	13874

Rat	epiregulin	RGD:620299	59325

Horse	epiregulin	VGNC:17659	100056605

Cow	epiregulin	VGNC:28575	100295476

Species	Name	OMA	EggNOG	Inparanoid
Chimp	epiregulin

Mouse	epiregulin

Rat	epiregulin

Horse	epiregulin

Cow	epiregulin

Protein Structure (4 Structures, 1 AlphaFold Model)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (179)

Reactome (48)

KEGG (4)

PathwayCommons (10)

WikiPathways (117)

Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 48

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825

Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828

Reactome	Constitutive Signaling by Aberrant PI3K in Cancer	75 targets	R-HSA-2219530

Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	Disease	1105 targets	R-HSA-1643685

Name	Explore in Pharos	Explore in Source
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825

Clathrin-mediated endocytosis	143 targets	R-HSA-8856828

Constitutive Signaling by Aberrant PI3K in Cancer	75 targets	R-HSA-2219530

Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Disease	1105 targets	R-HSA-1643685

Gene Ontology Terms (46)

Functions (5)

Components (3)

Processes (38)

Items per page:

1 – 5 of 5

GO Term	Evidence	Assigned by
growth factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

epidermal growth factor receptor binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Traceable Author Statement (TAS)	Reactome

protein tyrosine kinase activity	Traceable Author Statement (TAS)	Reactome

Ras guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (97)

1 – 10 of 97

See Interactions on String-DB

RAB4A

Tbio

Family: Enzyme

Novelty: 0.00423197

p_int: 0.986377374

p_ni: 0.011467036

p_wrong: 0.00215559

Score: 0.461

Data Source: BioPlex,STRINGDB

TMX4

Tdark

Novelty: 0.2628295

p_int: 0.949066073

p_ni: 0.050933927

Score: 0.28

Data Source: BioPlex,STRINGDB

LGALS1

Tchem

Novelty: 0.00106509

p_int: 0.822335311

p_ni: 0.177635592

p_wrong: 0.000029097

Score: 0.377

Data Source: BioPlex,STRINGDB

EGFR

Tclin

Family: Kinase

Novelty: 0.00007274

Score: 0.998