Protein Summary
Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]
- ENST00000244869
- ENSP00000244869
- ENSG00000124882
- ER
- Ep
- EPR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
gene perturbation | 0.98 | ||
PubMedID | 0.77 | ||
microRNA | 0.7 | ||
histone modification site profile | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 333 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 333 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 43
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (97)
RAB4A
Family: Enzyme
Novelty: 0.00423197
p_int: 0.986377374
p_ni: 0.011467036
p_wrong: 0.00215559
Score: 0.461
Data Source: BioPlex,STRINGDB
TMX4
Novelty: 0.2628295
p_int: 0.949066073
p_ni: 0.050933927
Score: 0.28
Data Source: BioPlex,STRINGDB
LGALS1
Novelty: 0.00106509
p_int: 0.822335311
p_ni: 0.177635592
p_wrong: 0.000029097
Score: 0.377
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (179)
Reactome (48)
KEGG (4)
PathwayCommons (10)
WikiPathways (117)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (46)
Functions (5)
Components (3)
Processes (38)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
balding measurement | 1 | 2 | 2 | 71 | |||||
response to allogeneic hematopoietic stem cell transplant | 1 | 1 | 0 | 2.7 | 54.2 | ||||
mortality | 1 | 1 | 0 | 2.7 | 54.2 | ||||
hair color | 1 | 1 | 0 | 1.1 | 33.7 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
balding measurement | 2 | 71 | |||||
response to allogeneic hematopoietic stem cell transplant | 0 | 2.7 | 54.2 | ||||
mortality | 0 | 2.7 | 54.2 | ||||
hair color | 0 | 1.1 | 33.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | epiregulin | VGNC:10858 | 740028 | |||||
Mouse | MGI:107508 | 13874 | ||||||
Rat | RGD:620299 | 59325 | ||||||
Horse | epiregulin | VGNC:17659 | 100056605 | |||||
Cow | epiregulin | VGNC:28575 | 100295476 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | epiregulin | |||||
Mouse | ||||||
Rat | ||||||
Horse | epiregulin | |||||
Cow | epiregulin | |||||
Publication Statistics
PubMed Score 333.00
PubMed score by year
PubTator Score 66.67
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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