Pharos : Target Details

Tbio

Protein Summary

Description

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

Gene Name

EREG

Ensembl ID

ENST00000244869
ENSP00000244869
ENSG00000124882

Symbol

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1

gene perturbation	0.98

PubMedID	0.77

microRNA	0.7

histone modification site profile	0.68

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.41 (req: < 5)

View Publications

Gene RIFs: 42 (req: <= 3)

View Gene RIFs

Antibodies: 260 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.41 (req: >= 5)

Gene RIFs: 42 (req: > 3)

Antibodies: 260 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (97)

Explore Interacting Targets

1 – 10 of 97

See Interactions on String-DB

RAB4A

Tbio

Family: Enzyme

Novelty: 0.00423197

p_int: 0.986377374

p_ni: 0.011467036

p_wrong: 0.00215559

Score: 0.461

Data Source: BioPlex,STRINGDB

TMX4

Tdark

Novelty: 0.2628295

p_int: 0.949066073

p_ni: 0.050933927

Score: 0.28

Data Source: BioPlex,STRINGDB

LGALS1

Tchem

Novelty: 0.00106509

p_int: 0.822335311

p_ni: 0.177635592

p_wrong: 0.000029097

Score: 0.377

Data Source: BioPlex,STRINGDB

EGFR

Tclin

Family: Kinase

Novelty: 0.00007274

Score: 0.998