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Tchem
PLD2
Phospholipase D2

Protein Summary
Description
May have a role in signal-induced cytoskeletal regulation and/or endocytosis. The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263088
  • ENSP00000263088
  • ENSG00000129219
  • ENST00000572940
  • ENSP00000459571

Symbol
  • PLD1C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.96
protein domain
0.92
kinase
0.9
hub protein
0.85
biological term
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.39   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.39   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
70.9
1
1
0
1.3
29.5
sleep duration
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
70.9
0
1.3
29.5
sleep duration
1
5.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase D2
VGNC:9528
454454
Macaque
phospholipase D2
721573
Mouse
MGI:892877
18806
Rat
RGD:3350
25097
Dog
phospholipase D2
VGNC:44661
479473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase D2
Macaque
phospholipase D2
Mouse
Rat
Dog
phospholipase D2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14939-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (152)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Metabolism
Protein-Protein Interactions (230)
1 – 10 of 230
CACNG5
Tdark
Family: IC
Novelty: 0.52705448
p_int: 0.997278519
p_ni: 0.002721481
Data Source: BioPlex
CHRM3
Tclin
Family: GPCR
Novelty: 0.00849776
p_int: 0.995630811
p_ni: 0.004369189
Score: 0.307
Data Source: BioPlex,STRINGDB
TUBB
Tclin
Novelty: 0.0038007
p_int: 0.995361263
p_ni: 0.004638737
Data Source: BioPlex
CIB2
Tbio
Novelty: 0.03578691
p_int: 0.989661407
p_ni: 0.010338591
p_wrong: 2e-9
Data Source: BioPlex
CDK5RAP3
Tbio
Novelty: 0.03628071
p_int: 0.985406912
p_ni: 0.014593088
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.983789946
p_ni: 0.016210054
Score: 0.152
Data Source: BioPlex,STRINGDB
SPC24
Tbio
Novelty: 0.03166479
p_int: 0.982206045
p_ni: 0.017793955
Score: 0.166
Data Source: BioPlex,STRINGDB
CDH8
Tbio
Novelty: 0.04055999
p_int: 0.973156279
p_ni: 0.026843721
Score: 0.163
Data Source: BioPlex,STRINGDB
DNAJC7
Tbio
Novelty: 0.02133191
p_int: 0.971272134
p_ni: 0.028727866
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.957746509
p_ni: 0.042253491
Data Source: BioPlex
Publication Statistics
PubMed Score  342.39

PubMed score by year
PubTator Score  150.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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