CASK
Peripheral plasma membrane protein CASK
Protein Summary
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, intellectual disability and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability. Multiple transcript variants encoding different isoforms ...more
- ENST00000378154
- ENSP00000367396
- ENSG00000147044
- ENST00000378163
- ENSP00000367405
- ENST00000421587
- ENSP00000400526
- ENST00000644347
- ENSP00000494183
- ENST00000645566
- ENSP00000494788
- LIN2
- CMG
- FGS4
- LIN2
- TNRC8
- hCASK
- CAGH39
- CAMGUK
- MICPCH
- MRXSNA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.99 | ||
molecular function | 0.97 | ||
transcription factor perturbation | 0.97 | ||
interacting protein | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 161.94 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 272 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 161.94 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 272 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0