You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CASK
Peripheral plasma membrane protein CASK

Protein Summary
Description
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, intellectual disability and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability. Multiple transcript variants encoding different isoforms ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378154
  • ENSP00000367396
  • ENSG00000147044
  • ENST00000378163
  • ENSP00000367405
  • ENST00000421587
  • ENSP00000400526
  • ENST00000644347
  • ENSP00000494183
  • ENST00000645566
  • ENSP00000494788

Symbol
  • LIN2
  • CMG
  • FGS4
  • LIN2
  • TNRC8
  • hCASK
  • CAGH39
  • CAMGUK
  • MICPCH
  • MRXSNA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.99
molecular function
0.97
transcription factor perturbation
0.97
interacting protein
0.9


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.24   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.24   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent serine protein kinase
VGNC:14818
100608149
Macaque
calcium/calmodulin dependent serine protein kinase
707428
Mouse
MGI:1309489
12361
Rat
RGD:62004
29647
Dog
calcium/calmodulin dependent serine protein kinase
VGNC:38729
480887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent serine protein kinase
Macaque
calcium/calmodulin dependent serine protein kinase
Mouse
Rat
Dog
calcium/calmodulin dependent serine protein kinase
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14936-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Cell-Cell communication
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Cell-Cell communication
Dopamine Neurotransmitter Release Cycle
Extracellular matrix organization
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (198)
1 – 10 of 198
LIN7C
Tbio
Novelty: 0.06778878
p_int: 1
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
LIN7B
Tbio
Novelty: 0.12689192
p_int: 0.999999977
p_ni: 2.4e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SPATA2
Tbio
Novelty: 0.10553772
p_int: 0.999757683
p_ni: 0.000242317
Score: 0.552
Data Source: BioPlex,STRINGDB
ZNF414
Tdark
Novelty: 1.29024829
p_int: 0.998273663
p_ni: 0.001726336
p_wrong: 1e-9
Score: 0.172
Data Source: BioPlex,STRINGDB
PTPDC1
Tdark
Family: Enzyme
Novelty: 0.38792241
p_int: 0.995712707
p_ni: 0.004287277
p_wrong: 1.5e-8
Score: 0.236
Data Source: BioPlex,STRINGDB
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.968733452
p_ni: 0.031266545
p_wrong: 3e-9
Score: 0.151
Data Source: BioPlex,STRINGDB
MYBPHL
Tdark
Novelty: 0.31786873
p_int: 0.924610166
p_ni: 0.075389831
p_wrong: 3e-9
Score: 0.523
Data Source: BioPlex,STRINGDB
MYCL
Tbio
Family: TF
Novelty: 0.0034508
p_int: 0.92366896
p_ni: 0.076331039
p_wrong: 1e-9
Data Source: BioPlex
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.895395715
p_ni: 0.104604278
p_wrong: 6e-9
Score: 0.154
Data Source: BioPlex,STRINGDB
EIF1AD
Tdark
Novelty: 0.23915521
p_int: 0.886174651
p_ni: 0.113825349
Data Source: BioPlex
Publication Statistics
PubMed Score  120.24

PubMed score by year
PubTator Score  120.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: