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Tbio
UBE2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

Protein Classes
Protein Summary
Description
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287156
  • ENSP00000287156
  • ENSG00000156587
  • ENST00000340573
  • ENSP00000341980

Symbol
  • UBCH8
  • RIG-B
  • UBCH8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.96
gene perturbation
0.92
transcription factor perturbation
0.84
cell type or tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.16   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.16   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amyloid fiber formation
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Antiviral mechanism by IFN-stimulated genes
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (381)
1 – 10 of 381
ARIH2
Tbio
Family: Enzyme
Novelty: 0.03316313
p_int: 0.999999896
p_ni: 8.7e-8
p_wrong: 1.7e-8
Score: 0.953
Data Source: BioPlex,STRINGDB
UBA6
Tchem
Novelty: 0.11710037
p_int: 0.999919814
p_ni: 0.000080186
Score: 0.964
Data Source: BioPlex,STRINGDB
HERC6
Tdark
Family: Enzyme
Novelty: 0.22411953
p_int: 0.999423888
p_ni: 0.000011581
p_wrong: 0.000564532
Score: 0.995
Data Source: BioPlex,STRINGDB
GPIHBP1
Tbio
Novelty: 0.01411894
p_int: 0.996830348
p_ni: 0.001803063
p_wrong: 0.001366589
Data Source: BioPlex
RPS27A
Tbio
Novelty: 0.01148413
Score: 0.995
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.994
Data Source: STRINGDB
HERC5
Tbio
Family: Enzyme
Novelty: 0.02247232
Score: 0.994
Data Source: Reactome,STRINGDB
ISG15
Tbio
Novelty: 0.00256125
Score: 0.993
Data Source: Reactome,STRINGDB
UBA7
Tbio
Novelty: 0.02293227
Score: 0.992
Data Source: Reactome,STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00108351
Score: 0.991
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  14.16

PubMed score by year
PubTator Score  24.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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