Tbio NCR3 Natural cytotoxicity triggering receptor 3

Protein Summary

Description

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• O14931
• B0S8F2
• B0S8F4
• B0S8F5
• O14930
• O14932
• O95667
• O95668
• O95669
• Q5ST89
• Q5ST90
• Q5ST91
• Q5ST92
• Q5STA3

Gene Name

• NCR3

Ensembl ID

• ENST00000340027
• ENSP00000342156
• ENSG00000204475
• ENST00000376071
• ENSP00000365239
• ENST00000376072
• ENSP00000365240
• ENST00000376073
• ENSP00000365241
• ENST00000383476
• ENSP00000372968
• ENSG00000206430
• ENST00000383477
• ENSP00000372969
• ENST00000383478
• ENSP00000372970
• ENST00000400241
• ENSP00000383100
• ENST00000412603
• ENSP00000389419
• ENSG00000225211
• ENST00000415123
• ENSP00000416944
• ENSG00000237103
• ENST00000418936
• ENSP00000402904
• ENSG00000237808
• ENST00000419086
• ENSP00000416105
• ENSG00000223833
• ENST00000419728
• ENSP00000406373
• ENSG00000236315
• ENST00000420485
• ENSP00000412474
• ENST00000420556
• ENSP00000405306
• ENST00000430599
• ENSP00000416035
• ENSG00000236979
• ENST00000432392
• ENSP00000409874
• ENST00000433654
• ENSP00000391177
• ENST00000435674
• ENSP00000390131
• ENST00000436253
• ENSP00000395238
• ENST00000436623
• ENSP00000404747
• ENST00000437517
• ENSP00000398313
• ENST00000438663
• ENSP00000415697
• ENST00000439584
• ENSP00000408960
• ENST00000441372
• ENSP00000399128
• ENST00000446756
• ENSP00000411205
• ENST00000447248
• ENSP00000389071
• ENST00000452296
• ENSP00000403978
• ENST00000453657
• ENSP00000409048
• ENST00000455448
• ENSP00000415456
• ENST00000455825
• ENSP00000389396
• ENST00000457547
• ENSP00000412702

Symbol

• 1C7
• LY117
• 1C7
• MALS
• CD337
• LY117
• NKp30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
biological term	0.68
tissue	0.65
disease	0.61
gene perturbation	0.61

Protein Classes

DTO Classes

Natural Cytotoxicity Triggering Receptor 3 Ligand 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: < 5)

Gene RIFs: 73   (req: <= 3)

Antibodies: 409   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: >= 5)

Gene RIFs: 73   (req: > 3)

Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0