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Tbio
NCR3
Natural cytotoxicity triggering receptor 3

Protein Classes
Protein Summary
Description
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340027
  • ENSP00000342156
  • ENSG00000204475
  • ENST00000376071
  • ENSP00000365239
  • ENST00000376072
  • ENSP00000365240
  • ENST00000376073
  • ENSP00000365241
  • ENST00000383476
  • ENSP00000372968
  • ENSG00000206430
  • ENST00000383477
  • ENSP00000372969
  • ENST00000383478
  • ENSP00000372970
  • ENST00000400241
  • ENSP00000383100
  • ENST00000412603
  • ENSP00000389419
  • ENSG00000225211
  • ENST00000415123
  • ENSP00000416944
  • ENSG00000237103
  • ENST00000418936
  • ENSP00000402904
  • ENSG00000237808
  • ENST00000419086
  • ENSP00000416105
  • ENSG00000223833
  • ENST00000419728
  • ENSP00000406373
  • ENSG00000236315
  • ENST00000420485
  • ENSP00000412474
  • ENST00000420556
  • ENSP00000405306
  • ENST00000430599
  • ENSP00000416035
  • ENSG00000236979
  • ENST00000432392
  • ENSP00000409874
  • ENST00000433654
  • ENSP00000391177
  • ENST00000435674
  • ENSP00000390131
  • ENST00000436253
  • ENSP00000395238
  • ENST00000436623
  • ENSP00000404747
  • ENST00000437517
  • ENSP00000398313
  • ENST00000438663
  • ENSP00000415697
  • ENST00000439584
  • ENSP00000408960
  • ENST00000441372
  • ENSP00000399128
  • ENST00000446756
  • ENSP00000411205
  • ENST00000447248
  • ENSP00000389071
  • ENST00000452296
  • ENSP00000403978
  • ENST00000453657
  • ENSP00000409048
  • ENST00000455448
  • ENSP00000415456
  • ENST00000455825
  • ENSP00000389396
  • ENST00000457547
  • ENSP00000412702

Symbol
  • 1C7
  • LY117
  • 1C7
  • MALS
  • CD337
  • LY117
  • NKp30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
biological term
0.68
tissue
0.65
disease
0.61
gene perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.27   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.27   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (658)
Items per page:
1 – 5 of 658
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
4
5
97.5
lymphocyte count
3
4
5
97.5
lymphocyte count
3
4
5
97.5
lymphocyte count
3
4
5
97.5
lymphocyte count
3
4
5
97.5
Items per page:
1 – 5 of 658
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
97.5
lymphocyte count
5
97.5
lymphocyte count
5
97.5
lymphocyte count
5
97.5
lymphocyte count
5
97.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
natural cytotoxicity triggering receptor 3
VGNC:11131
449613
Macaque
natural cytotoxicity triggering receptor 3
715574
Rat
RGD:727881
294251
Dog
natural cytotoxicity triggering receptor 3
VGNC:43666
607220
Horse
natural cytotoxicity triggering receptor 3
VGNC:20604
100058447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
natural cytotoxicity triggering receptor 3
Macaque
natural cytotoxicity triggering receptor 3
Rat
Dog
natural cytotoxicity triggering receptor 3
Horse
natural cytotoxicity triggering receptor 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14931-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (176)
1 – 10 of 176
NCR3LG1
Tbio
Novelty:  0.02681936
Score:  0.998
Data Source:  Reactome,STRINGDB
CD247
Tbio
Novelty:  0.00217194
Score:  0.929
Data Source:  Reactome,STRINGDB
NCR2
Tbio
Novelty:  0.00685029
Score:  0.92
Data Source:  STRINGDB
NCR1
Tbio
Novelty:  0.00282259
Score:  0.92
Data Source:  STRINGDB
KLRK1
Tbio
Novelty:  0.0009209
Score:  0.913
Data Source:  STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.912
Data Source:  Reactome,STRINGDB
CD226
Tbio
Novelty:  0.00374102
Score:  0.843
Data Source:  STRINGDB
KLRC1
Tbio
Novelty:  0.00312379
Score:  0.84
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.832
Data Source:  STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
Score:  0.809
Data Source:  STRINGDB
Publication Statistics
PubMed Score  232.27

PubMed score by year
PubTator Score  206.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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