Tbio HAT1 Histone acetyltransferase type B catalytic subunit

Protein Summary

Description

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• O14929
• Q49A44
• Q53QF0
• Q53SU4
• Q6P594
• Q8WWB9

Gene Name

• HAT1

Ensembl ID

• ENST00000264108
• ENSP00000264108
• ENSG00000128708

Symbol

• KAT1
• KAT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
co-expressed gene	0.99
interacting protein	0.9
hub protein	0.75
histone modification site profile	0.71

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Histone Acetyltransferase Type B Catalytic Subunit

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Histone Acetyltransferase Type B Catalytic Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.03   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 366   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.03   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0