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Tbio
TIMM23
Mitochondrial import inner membrane translocase subunit Tim23

Protein Summary
Description
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000580018
  • ENSP00000464522
  • ENSG00000265354

Symbol
  • TIM23
  • TIM23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
virus perturbation
0.98
kinase perturbation
0.97
histone modification site profile
0.79
cellular component
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.85   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.85   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
3
4
95.2
mean corpuscular hemoglobin concentration
2
2
2
93.9
mean corpuscular hemoglobin
3
3
3
93.8
14
2
1
1.2
89.7
red blood cell density measurement
2
2
2
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
95.2
mean corpuscular hemoglobin concentration
2
93.9
mean corpuscular hemoglobin
3
93.8
1
1.2
89.7
red blood cell density measurement
2
89.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
translocase of inner mitochondrial membrane 23 homolog (yeast)
709594
Mouse
MGI:1858317
53600
Cow
translocase of inner mitochondrial membrane 23 homolog (yeast)
509841
Xenopus
translocase of inner mitochondrial membrane 23 homolog
XB-GENE-994532
496463
Species
Name
OMA
EggNOG
Inparanoid
Macaque
translocase of inner mitochondrial membrane 23 homolog (yeast)
Mouse
Cow
translocase of inner mitochondrial membrane 23 homolog (yeast)
Xenopus
translocase of inner mitochondrial membrane 23 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14925-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Protein-Protein Interactions (135)
1 – 10 of 135
SLC2A8
Tbio
Family:  Transporter
Novelty:  0.02075375
p_int:  0.985969229
p_ni:  0.009226045
p_wrong:  0.004804726
Score:  0.198
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.979089217
p_ni:  0.020910782
p_wrong:  1e-9
Data Source:  BioPlex
TMEM184B
Tdark
Novelty:  0.35340207
p_int:  0.971181302
p_ni:  0.028818698
Score:  0.165
Data Source:  BioPlex,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.917083666
p_ni:  0.082916334
Data Source:  BioPlex
RUFY1
Tbio
Novelty:  0.16796947
p_int:  0.915850557
p_ni:  0.083478545
p_wrong:  0.000670898
Score:  0.173
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.848055751
p_ni:  0.151944249
Data Source:  BioPlex
PIKFYVE
Tchem
Family:  Kinase
Novelty:  0.00441336
p_int:  0.84013223
p_ni:  0.159746701
p_wrong:  0.00012107
Score:  0.197
Data Source:  BioPlex,STRINGDB
TIMM17A
Tbio
Family:  Enzyme
Novelty:  0.02095904
Score:  0.999
Data Source:  STRINGDB
TIMM17B
Tdark
Family:  Enzyme
Novelty:  0.03556998
Score:  0.999
Data Source:  STRINGDB
TIMM13
Tdark
Family:  Enzyme
Novelty:  0.04802297
Score:  0.996
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.85

PubMed score by year
PubTator Score  64.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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