Tbio RGS12 Regulator of G-protein signaling 12

Protein Summary

Description

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14924
• B1AQ30
• B1AQ31
• B1AQ32
• B7Z764
• E7EMN9
• O14922
• O14923
• O43510
• O75338
• Q147X0
• Q8WX95
• RGS12

Gene Name

• RGS12

Ensembl ID

• ENST00000336727
• ENSP00000338509
• ENSG00000159788
• ENST00000338806
• ENSP00000342133
• ENST00000344733
• ENSP00000339381
• ENST00000382788
• ENSP00000372238

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor perturbation	0.96
small molecule perturbation	0.87
cell type or tissue	0.73
transcription factor	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.5   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.5   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0