You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RGS12
Regulator of G-protein signaling 12

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336727
  • ENSP00000338509
  • ENSG00000159788
  • ENST00000338806
  • ENSP00000342133
  • ENST00000344733
  • ENSP00000339381
  • ENST00000382788
  • ENSP00000372238
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.96
small molecule perturbation
0.87
cell type or tissue
0.73
transcription factor
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.47   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.47   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999999992
p_ni:  3e-9
p_wrong:  4e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
p_int:  0.999999976
p_ni:  3e-9
p_wrong:  2.2e-8
Score:  0.986
Data Source:  BioPlex,STRINGDB
ARL4C
Tbio
Family:  Enzyme
Novelty:  0.04764628
p_int:  0.999987339
p_ni:  0.000010426
p_wrong:  0.000002234
Score:  0.298
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.95
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.932
Data Source:  STRINGDB
GPSM2
Tbio
Novelty:  0.00941766
Score:  0.778
Data Source:  STRINGDB
GPSM1
Tbio
Novelty:  0.03510582
Score:  0.773
Data Source:  STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
Score:  0.711
Data Source:  STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
Score:  0.698
Data Source:  STRINGDB
CXCR2
Tchem
Family:  GPCR
Novelty:  0.00108314
Score:  0.684
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (51)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
10
9
18
98.1
low density lipoprotein cholesterol measurement
6
5
7
97
serum albumin measurement
2
8
8
96.4
testosterone measurement
5
6
7
94.8
hepatocyte growth factor measurement
3
4
2
29.3
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
18
98.1
low density lipoprotein cholesterol measurement
7
97
serum albumin measurement
8
96.4
testosterone measurement
7
94.8
hepatocyte growth factor measurement
2
29.3
94.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 12
VGNC:2003
461085
Macaque
regulator of G protein signaling 12
699927
Mouse
MGI:1918979
71729
Rat
RGD:3564
54292
Dog
regulator of G protein signaling 12
VGNC:45522
608720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 12
Macaque
regulator of G protein signaling 12
Mouse
Rat
Dog
regulator of G protein signaling 12
Publication Statistics
PubMed Score 45.47
PubMed score by year
PubTator Score 15.15
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title