Tbio RGS13 Regulator of G-protein signaling 13

Protein Summary

Description

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity). The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14921
• Q6PGR2
• Q8TD63
• Q9BX45
• RGS13

Gene Name

• RGS13

Ensembl ID

• ENST00000391995
• ENSP00000375853
• ENSG00000127074
• ENST00000543215
• ENSP00000442837

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.63
gene perturbation	0.61
phenotype	0.56
PubMedID	0.51
cell line	0.49

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulator Of G-protein Signaling 13

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulator Of G-protein Signaling 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.34   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.34   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0