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Tchem
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

Protein Summary
Description
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000416505
  • ENSP00000404920
  • ENSG00000104365
  • ENST00000520810
  • ENSP00000430684
  • ENST00000520835
  • ENSP00000430868
  • ENST00000649612
  • ENSP00000497383

Symbol
  • IKKB
  • IKK2
  • IKKB
  • IMD15
  • IMD15A
  • IMD15B
  • NFKBIKB
  • IKK-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological term
0.99
chemical
0.99
kinase
0.99
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1159.2   (req: < 5)
Gene RIFs: 229   (req: <= 3)
Antibodies: 2128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1159.2   (req: >= 5)
Gene RIFs: 229   (req: > 3)
Antibodies: 2128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 221
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0