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Tchem
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

Protein Summary
Description
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000416505
  • ENSP00000404920
  • ENSG00000104365
  • ENST00000520810
  • ENSP00000430684
  • ENST00000520835
  • ENSP00000430868
  • ENST00000649612
  • ENSP00000497383

Symbol
  • IKKB
  • IKK2
  • IKKB
  • IMD15
  • IMD15A
  • IMD15B
  • NFKBIKB
  • IKK-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological term
0.99
chemical
0.99
kinase
0.99
molecular function
0.99


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1086.69   (req: < 5)
Gene RIFs: 229   (req: <= 3)
Antibodies: 2128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1086.69   (req: >= 5)
Gene RIFs: 229   (req: > 3)
Antibodies: 2128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 221
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (221)
1 – 10 of 221
staurosporine
Rendered image for staurosporine
lestaurtinib
Rendered image for lestaurtinib
CHEMBL129857
Rendered image for CHEMBL129857
BMS-345541
Rendered image for BMS-345541
compound 47 [PMID: 28737909]
Rendered image for compound 47 [PMID: 28737909]
PHA-408
Rendered image for PHA-408
IKK-2 inhibitor IV
Rendered image for IKK-2 inhibitor IV
CHEMBL2164412
Rendered image for CHEMBL2164412
CHEMBL2164410
Rendered image for CHEMBL2164410
CHEMBL2164411
Rendered image for CHEMBL2164411
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tissue plasminogen activator measurement
1
2
2
49.2
1
1
0
1.9
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tissue plasminogen activator measurement
2
49.2
0
1.9
17.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
inhibitor of nuclear factor kappa B kinase subunit beta
704683
Mouse
MGI:1338071
16150
Rat
RGD:621375
84351
Dog
inhibitor of nuclear factor kappa B kinase subunit beta
VGNC:51803
482839
Cow
inhibitor of nuclear factor kappa B kinase subunit beta
281854
Species
Name
OMA
EggNOG
Inparanoid
Macaque
inhibitor of nuclear factor kappa B kinase subunit beta
Mouse
Rat
Dog
inhibitor of nuclear factor kappa B kinase subunit beta
Cow
inhibitor of nuclear factor kappa B kinase subunit beta
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14920-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (216)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 66
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing-Cross presentation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Gene Ontology Terms (44)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (267)
1 – 10 of 267
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
p_int:  0.999999996
p_ni:  2e-9
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MAP3K14
Tchem
Family:  Kinase
Novelty:  0.0350173
p_int:  0.999999019
p_ni:  9.8e-7
p_wrong:  1e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
PSG1
Tbio
Novelty:  0.0239046
p_int:  0.999997657
p_ni:  0.000002343
Score:  0.622
Data Source:  BioPlex,STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
p_int:  0.996745796
p_ni:  0.000002203
p_wrong:  0.003252
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.999
Data Source:  STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
Score:  0.999
Data Source:  Reactome,STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.997
Data Source:  Reactome,STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
Score:  0.995
Data Source:  Reactome,STRINGDB
BCL10
Tbio
Novelty:  0.00253704
Score:  0.993
Data Source:  Reactome,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.991
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  1086.69

PubMed score by year
PubTator Score  622.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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