Tbio PCDH17 Protocadherin-17

Protein Summary

Description

Potential calcium-dependent cell-adhesion protein. This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14917
• A8K1R5
• Q5VVW9
• Q5VVX0

Gene Name

• PCDH17

Ensembl ID

• ENST00000377918
• ENSP00000367151
• ENSG00000118946
• ENST00000484979
• ENSP00000432899

Symbol

• PCDH68
• PCH68
• PCH68
• PCDH68

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.89
PubMedID	0.86
transcription factor	0.68
transcription factor perturbation	0.68
histone modification site profile	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.96   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.96   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0