Tbio LIN7A Protein lin-7 homolog A

Protein Summary

Description

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• O14910
• A4FTY3
• Q147W1
• Q6LES3
• Q7LDS4
• Lin-7A

Gene Name

• LIN7A

Ensembl ID

• ENST00000552864
• ENSP00000447488
• ENSG00000111052

Symbol

• MALS1
• VELI1
• LIN7
• MALS1
• VELI1
• LIN-7A
• MALS-1
• TIP-33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
interacting protein	0.72
virus perturbation	0.72
cellular component	0.67
tissue sample	0.56

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Protein Lin-7 Homolog A

Protein / Cell Adhesion Molecule / Protein Lin-7 Homolog A

DTO Classes

Protein / Cell-cell Junction / Protein Lin-7 Homolog A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.71   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.71   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0