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Tbio
GIPC1
PDZ domain-containing protein GIPC1

Protein Summary
Description
May be involved in G protein-linked signaling. GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345425
  • ENSP00000340698
  • ENSG00000123159
  • ENST00000393028
  • ENSP00000376748
  • ENST00000393033
  • ENSP00000376753
  • ENST00000586027
  • ENSP00000466747
  • ENST00000591349
  • ENSP00000467077

Symbol
  • C19orf3
  • GIPC
  • RGS19IP1
  • NIP
  • GIPC
  • IIP-1
  • TIP-2
  • SEMCAP
  • C19orf3
  • Hs.6454
  • GLUT1CBP
  • RGS19IP1
  • SYNECTIN
  • SYNECTIIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
biological process
0.78
disease perturbation
0.68
tissue
0.68
cellular component
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.25   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.25   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
89.8
myeloid white cell count
1
1
1
71.2
lymphocyte count
1
1
1
70.5
leukocyte count
1
1
1
67.7
reticulocyte count
2
1
2
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
89.8
myeloid white cell count
1
71.2
lymphocyte count
1
70.5
leukocyte count
1
67.7
reticulocyte count
2
65.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GIPC PDZ domain containing family member 1
VGNC:11121
747668
Macaque
GIPC PDZ domain containing family member 1
717785
Mouse
MGI:1926252
67903
Rat
RGD:68338
83823
Dog
GIPC PDZ domain containing family member 1
VGNC:41225
484902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GIPC PDZ domain containing family member 1
Macaque
GIPC PDZ domain containing family member 1
Mouse
Rat
Dog
GIPC PDZ domain containing family member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14908-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: netpath
TGF_beta_Receptor
PathwayCommons: pid
Neurotrophic factor-mediated Trk receptor signaling
PathwayCommons: pid
Syndecan-4-mediated signaling events
Name
Explore in Pharos
Explore in Source
TGF_beta_Receptor
Neurotrophic factor-mediated Trk receptor signaling
Syndecan-4-mediated signaling events
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (110)
1 – 10 of 110
RGS19
Tchem
Novelty:  0.0159403
Score:  0.997
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.981
Data Source:  STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.977
Data Source:  STRINGDB
MYO6
Tbio
Novelty:  0.01073438
Score:  0.971
Data Source:  STRINGDB
NTRK2
Tclin
Family:  Kinase
Novelty:  0.00054534
Score:  0.97
Data Source:  STRINGDB
BDNF
Tchem
Novelty:  0.00006891
Score:  0.92
Data Source:  STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.92
Data Source:  STRINGDB
DYNLT1
Tbio
Novelty:  0.00336045
Score:  0.906
Data Source:  STRINGDB
DNM1
Tbio
Novelty:  0.00319082
Score:  0.901
Data Source:  STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.897
Data Source:  STRINGDB
Publication Statistics
PubMed Score  134.25

PubMed score by year
PubTator Score  95.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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