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Tbio
TAX1BP3
Tax1-binding protein 3

Protein Summary
Description
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225525
  • ENSP00000225525
  • ENSG00000213977

Symbol
  • TIP1
  • TIP1
  • TIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.81
histone modification site profile
0.79
disease perturbation
0.74
virus perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.46   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.46   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Tax1 binding protein 3
VGNC:12717
454432
Macaque
Tax1 binding protein 3
706829
Mouse
MGI:1923531
76281
Rat
RGD:1308924
360564
Dog
Tax1 binding protein 3
VGNC:47126
100856105
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Tax1 binding protein 3
Macaque
Tax1 binding protein 3
Mouse
Rat
Dog
Tax1 binding protein 3
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14907-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Rhotekin and Rhophilins
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Rhotekin and Rhophilins
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (79)
1 – 10 of 79
CIT
Tchem
Family: Kinase
Novelty: 0.04094716
p_int: 1
Data Source: BioPlex
RTKN
Tbio
Novelty: 0.01044337
p_int: 0.999999994
p_ni: 6e-9
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
TANC1
Tdark
Novelty: 0.09147304
p_int: 0.999999961
p_ni: 3.9e-8
Data Source: BioPlex
UBL3
Tbio
Novelty: 0.12397801
p_int: 0.999999917
p_ni: 8.3e-8
Data Source: BioPlex
CDH3
Tbio
Novelty: 0.00295114
p_int: 0.999999911
p_ni: 8.4e-8
p_wrong: 5e-9
Data Source: BioPlex
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
p_int: 0.999999877
p_ni: 1.23e-7
Data Source: BioPlex
ARHGEF7
Tbio
Novelty: 0.00919946
p_int: 0.999999853
p_ni: 1.48e-7
Score: 0.43
Data Source: BioPlex,STRINGDB
PAK3
Tchem
Family: Kinase
Novelty: 0.02949319
p_int: 0.999999823
p_ni: 1.57e-7
p_wrong: 2e-8
Data Source: BioPlex
TANC2
Tdark
Novelty: 0.08495328
p_int: 0.999999813
p_ni: 1.86e-7
Data Source: BioPlex
PPP1R13L
Tbio
Novelty: 0.01378765
p_int: 0.999999462
p_ni: 5.38e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  69.46

PubMed score by year
PubTator Score  41.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer