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Tbio
WNT9B
Protein Wnt-9b

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity). The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WN ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290015
  • ENSP00000290015
  • ENSG00000158955
  • ENST00000613753
  • ENSP00000482127
  • ENSG00000276799

Symbol
  • WNT14B
  • WNT15
  • WNT15
  • WNT14B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
cell type or tissue
0.7
cell line
0.64
pathway
0.57
tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.42   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.42   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (154)
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.995905848
p_ni:  0.004094152
Score:  0.177
Data Source:  BioPlex,STRINGDB
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.99553969
p_ni:  0.00446031
Score:  0.204
Data Source:  BioPlex,STRINGDB
NDUFA2
Tclin
Family:  Enzyme
Novelty:  0.02698508
p_int:  0.901230285
p_ni:  0.098769705
p_wrong:  1e-8
Score:  0.416
Data Source:  BioPlex,STRINGDB
FZD1
Tchem
Family:  GPCR
Novelty:  0.01097201
Score:  0.978
Data Source:  STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
Score:  0.971
Data Source:  STRINGDB
FZD4
Tchem
Family:  GPCR
Novelty:  0.00577957
Score:  0.971
Data Source:  STRINGDB
FZD8
Tbio
Family:  GPCR
Novelty:  0.01613553
Score:  0.969
Data Source:  STRINGDB
WLS
Tbio
Novelty:  0.01459149
Score:  0.968
Data Source:  STRINGDB
FZD6
Tbio
Family:  GPCR
Novelty:  0.01425136
Score:  0.967
Data Source:  STRINGDB
FZD5
Tbio
Family:  GPCR
Novelty:  0.01673829
Score:  0.966
Data Source:  STRINGDB
Pathways (130)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (98)
Items per page:
1 – 5 of 98
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
1
4
4
94.5
serum urea measurement
1
4
4
94.5
neuroticism measurement
2
6
3
6.9
93.6
neuroticism measurement
2
6
3
6.9
93.6
blood urea nitrogen measurement
2
2
2
89.9
Items per page:
1 – 5 of 98
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
4
94.5
serum urea measurement
4
94.5
neuroticism measurement
3
6.9
93.6
neuroticism measurement
3
6.9
93.6
blood urea nitrogen measurement
2
89.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein Wnt-9b
468296
Macaque
Wnt family member 9B [Source:HGNC Symbol;Acc:HGNC:12779]
Mouse
MGI:1197020
22412
Rat
RGD:1309574
303586
Dog
Wnt family member 9B
VGNC:48431
490919
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein Wnt-9b
Macaque
Wnt family member 9B [Source:HGNC Symbol;Acc:HGNC:12779]
Mouse
Rat
Dog
Wnt family member 9B
Publication Statistics
PubMed Score 74.42
PubMed score by year
PubTator Score 22.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title