Tbio WNT9B Protein Wnt-9b

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity). The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• O14905
• Q6UXT4
• Q96Q09

Gene Name

• WNT9B

Ensembl ID

• ENST00000290015
• ENSP00000290015
• ENSG00000158955
• ENST00000613753
• ENSP00000482127
• ENSG00000276799

Symbol

• WNT14B
• WNT15
• WNT15
• WNT14B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.91
cell type or tissue	0.7
cell line	0.64
pathway	0.57
tissue	0.56

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-9b

DTO Classes

Protein / Signaling / Protein Wnt-9b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.76   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.76   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0