Tbio WNT9A Protein Wnt-9a

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14904
• A6NLW2
• Q2M2J3
• Q5VWU0
• Q96S50

Gene Name

• WNT9A

Ensembl ID

• ENST00000272164
• ENSP00000272164
• ENSG00000143816

Symbol

• WNT14
• WNT14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
pathway	0.66
transcription factor binding site profile	0.65
tissue sample	0.6
transcription factor	0.59

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-9a

DTO Classes

Protein / Signaling / Protein Wnt-9a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.1   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.1   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0