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Tbio
WNT9A
Protein Wnt-9a

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272164
  • ENSP00000272164
  • ENSG00000143816

Symbol
  • WNT14
  • WNT14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
pathway
0.66
transcription factor binding site profile
0.65
tissue sample
0.6
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.22   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.22   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Moyamoya disease
1
1
0
1.6
31.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Moyamoya disease
0
1.6
31.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 9A
VGNC:9403
469697
Macaque
Wnt family member 9A
696326
Mouse
MGI:2446084
216795
Dog
Wnt family member 9A
VGNC:54801
482209
Horse
Wnt family member 9A [Source:HGNC Symbol;Acc:HGNC:12778]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 9A
Macaque
Wnt family member 9A
Mouse
Dog
Wnt family member 9A
Horse
Wnt family member 9A [Source:HGNC Symbol;Acc:HGNC:12778]
Pathways (53)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (123)
1 – 10 of 123
LRP5
Tbio
Novelty: 0.00089807
Score: 0.979
Data Source: STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.978
Data Source: STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.973
Data Source: STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.972
Data Source: STRINGDB
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
Score: 0.971
Data Source: STRINGDB
WLS
Tbio
Novelty: 0.01459149
Score: 0.97
Data Source: STRINGDB
FZD4
Tchem
Family: GPCR
Novelty: 0.00577957
Score: 0.97
Data Source: STRINGDB
FZD8
Tbio
Family: GPCR
Novelty: 0.01613553
Score: 0.97
Data Source: STRINGDB
WIF1
Tbio
Novelty: 0.00548622
Score: 0.968
Data Source: Reactome,STRINGDB
FZD9
Tbio
Family: GPCR
Novelty: 0.01414546
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.22

PubMed score by year
PubTator Score  17.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer