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Tbio
KLF11
Krueppel-like factor 11

Protein Summary
Description
Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305883
  • ENSP00000307023
  • ENSG00000172059
  • ENST00000535335
  • ENSP00000442722
  • ENST00000540845
  • ENSP00000444690

Symbol
  • FKLF
  • TIEG2
  • FKLF
  • FKLF1
  • MODY7
  • TIEG2
  • Tieg3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
microRNA
0.82
biological process
0.73
transcription factor binding site profile
0.71
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.76   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.76   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (37)
1 – 10 of 37
SIN3A
Tbio
Novelty: 0.01059111
Score: 0.733
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00060382
Score: 0.698
Data Source: STRINGDB
MAOB
Tclin
Family: Enzyme
Novelty: 0.00036833
Score: 0.682
Data Source: STRINGDB
BLK
Tchem
Family: Kinase
Novelty: 0.00922757
Score: 0.669
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00019506
Score: 0.657
Data Source: STRINGDB
SMAD7
Tbio
Family: TF
Novelty: 0.00137901
Score: 0.636
Data Source: STRINGDB
EBF2
Tbio
Family: TF
Novelty: 0.00851499
Score: 0.626
Data Source: STRINGDB
MAOA
Tclin
Family: Enzyme
Novelty: 0.00037876
Score: 0.598
Data Source: STRINGDB
NR4A2
Tchem
Family: NR
Novelty: 0.00242111
Score: 0.593
Data Source: STRINGDB
PAX4
Tbio
Family: TF
Novelty: 0.00688976
Score: 0.558
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.76

PubMed score by year
PubTator Score  40.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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