You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GEMIN2
Gem-associated protein 2

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localiz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250379
  • ENSP00000250379
  • ENSG00000092208
  • ENST00000308317
  • ENSP00000308533
  • ENST00000396249
  • ENSP00000379548
  • ENST00000412033
  • ENSP00000416827

Symbol
  • SIP1
  • SIP1
  • SIP1-delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.87
kinase perturbation
0.84
interacting protein
0.78
cellular component
0.7
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.66   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.66   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
DDX20
Tbio
Family:  Enzyme
Novelty:  0.01854078
p_int:  0.999943382
p_ni:  0.000056618
Score:  0.999
Data Source:  BioPlex,STRINGDB
STRN4
Tbio
Novelty:  0.09936184
p_int:  0.99989365
p_ni:  0.00010635
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.999794935
p_ni:  0.000205065
Score:  0.673
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.99900784
p_ni:  0.00099216
Data Source:  BioPlex
GEMIN6
Tbio
Novelty:  0.02104816
p_int:  0.998558095
p_ni:  0.001441905
Score:  0.998
Data Source:  BioPlex,STRINGDB
STRAP
Tbio
Family:  Enzyme
Novelty:  0.0336013
p_int:  0.998405497
p_ni:  0.001594503
Score:  0.992
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.99817862
p_ni:  0.001819933
p_wrong:  0.000001447
Score:  0.294
Data Source:  BioPlex,STRINGDB
LSM7
Tbio
Novelty:  0.09112723
p_int:  0.998039405
p_ni:  0.001960591
p_wrong:  4e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
GEMIN8
Tbio
Novelty:  0.19515325
p_int:  0.997918376
p_ni:  0.002081624
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.994746431
p_ni:  0.005253569
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
9
5
8
7
97.5
seasonality measurement
1
1
0
7
53.7
self reported educational attainment
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
8
7
97.5
seasonality measurement
0
7
53.7
self reported educational attainment
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 2
VGNC:3418
452873
Macaque
gem nuclear organelle associated protein 2
698881
Mouse
MGI:1913853
66603
Rat
RGD:620842
84404
Dog
gem nuclear organelle associated protein 2
VGNC:41173
610087
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 2
Macaque
gem nuclear organelle associated protein 2
Mouse
Rat
Dog
gem nuclear organelle associated protein 2
Publication Statistics
PubMed Score 47.66
PubMed score by year
PubTator Score 36.05
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title