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Tbio
IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

Protein Summary
Description
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371811
  • ENSP00000360876
  • ENSG00000119917
  • ENST00000371818
  • ENSP00000360883

Symbol
  • CIG-49
  • IFI60
  • IFIT4
  • ISG60
  • P60
  • IRG2
  • IFI60
  • IFIT4
  • ISG60
  • RIG-G
  • cig41
  • CIG-49
  • GARG-49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.92
protein domain
0.73
small molecule perturbation
0.66
disease
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.3   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.3   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon induced protein with tetratricopeptide repeats 3
VGNC:51978
738542
Macaque
interferon induced protein with tetratricopeptide repeats 3
695344
Mouse
MGI:1101055
15959
Mouse
MGI:3698419
667370
Rat
RGD:1359681
309526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon induced protein with tetratricopeptide repeats 3
Macaque
interferon induced protein with tetratricopeptide repeats 3
Mouse
Mouse
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14879-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (190)
1 – 10 of 190
PHACTR4
Tbio
Family: Enzyme
Novelty: 0.11366977
p_int: 0.999999932
p_ni: 6.6e-8
p_wrong: 2e-9
Score: 0.672
Data Source: BioPlex,STRINGDB
IFIT2
Tbio
Novelty: 0.01023074
p_int: 0.999999355
p_ni: 6.42e-7
p_wrong: 3e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
IFNA14
Tbio
Novelty: 0.17853653
p_int: 0.999988985
p_ni: 0.00001099
p_wrong: 2.5e-8
Score: 0.845
Data Source: BioPlex,STRINGDB
IFNA7
Tdark
Novelty: 0.14618009
p_int: 0.99942743
p_ni: 0.000025641
p_wrong: 0.000546929
Data Source: BioPlex
IFNA21
Tbio
Novelty: 0.00581034
p_int: 0.996498911
p_ni: 0.000089904
p_wrong: 0.003411185
Score: 0.668
Data Source: BioPlex,STRINGDB
IFNA8
Tbio
Novelty: 0.0310922
p_int: 0.995248987
p_ni: 0.000845282
p_wrong: 0.003905731
Score: 0.228
Data Source: BioPlex,STRINGDB
IFNA2
Tbio
Novelty: 0.00032935
p_int: 0.987570439
p_ni: 0.001102266
p_wrong: 0.011327295
Score: 0.902
Data Source: BioPlex,STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
Score: 0.999
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.996
Data Source: STRINGDB
OASL
Tbio
Family: Enzyme
Novelty: 0.01502223
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  170.30

PubMed score by year
PubTator Score  206.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer