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Tbio
BCKDK
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Protein Summary
Description
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219794
  • ENSP00000219794
  • ENSG00000103507
  • ENST00000287507
  • ENSP00000287507
  • ENST00000394950
  • ENSP00000378404
  • ENST00000394951
  • ENSP00000378405

Symbol
  • BDK
  • BCKDKD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
drug perturbation
0.87
ligand (protein) perturbation
0.83
disease perturbation
0.79
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (49)
1 – 10 of 49
METTL21C
Tbio
Family:  Enzyme
Novelty:  0.14890496
p_int:  0.999986614
p_ni:  0.000013384
p_wrong:  1e-9
Score:  0.466
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.997474324
p_ni:  0.002525676
Data Source:  BioPlex
CETN3
Tbio
Novelty:  0.00705513
p_int:  0.957902366
p_ni:  0.042097629
p_wrong:  5e-9
Score:  0.591
Data Source:  BioPlex,STRINGDB
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.923705045
p_ni:  0.076294955
Score:  0.553
Data Source:  BioPlex,STRINGDB
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.922136263
p_ni:  0.077863644
p_wrong:  9.2e-8
Score:  0.504
Data Source:  BioPlex,STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
p_int:  0.890255386
p_ni:  0.109744614
Score:  0.339
Data Source:  BioPlex,STRINGDB
NIT1
Tbio
Family:  Enzyme
Novelty:  0.00498587
p_int:  0.857386644
p_ni:  0.142612764
p_wrong:  5.92e-7
Score:  0.246
Data Source:  BioPlex,STRINGDB
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.853691112
p_ni:  0.146308864
p_wrong:  2.3e-8
Score:  0.168
Data Source:  BioPlex,STRINGDB
REC8
Tbio
Novelty:  0.00732742
p_int:  0.819488356
p_ni:  0.180509287
p_wrong:  0.000002357
Data Source:  BioPlex
GCNT3
Tbio
Family:  Enzyme
Novelty:  0.04356924
p_int:  0.808663216
p_ni:  0.191336784
Score:  0.204
Data Source:  BioPlex,STRINGDB
Pathways (4)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Sequence or structural Similarity (ISS)
HGNC
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
HGNC
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
82.8
response to anticoagulant
1
1
0
20.4
81
triglyceride measurement
3
3
3
72.3
body mass index
5
2
6
71.6
waist circumference
2
2
2
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
82.8
response to anticoagulant
0
20.4
81
triglyceride measurement
3
72.3
body mass index
6
71.6
waist circumference
2
67.4
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
branched chain ketoacid dehydrogenase kinase
VGNC:9042
741960
Macaque
branched chain ketoacid dehydrogenase kinase
712985
Mouse
MGI:1276121
12041
Rat
RGD:2198
29603
Dog
branched chain ketoacid dehydrogenase kinase
VGNC:38407
479776
Species
Name
OMA
EggNOG
Inparanoid
Chimp
branched chain ketoacid dehydrogenase kinase
Macaque
branched chain ketoacid dehydrogenase kinase
Mouse
Rat
Dog
branched chain ketoacid dehydrogenase kinase
Publication Statistics
PubMed Score 36.89
PubMed score by year
PubTator Score 19.49
PubTator score by year
Patents
Patents by year