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Tbio
BACH1
Transcription regulator protein BACH1

Protein Summary
Description
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286800
  • ENSP00000286800
  • ENSG00000156273
  • ENST00000399921
  • ENSP00000382805

Symbol
  • BACH-1
  • BTBD24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.9
microRNA
0.88
protein domain
0.85
transcription factor
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.17   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.17   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
73.3
creatine kinase measurement
1
1
1
52.2
body mass index
1
1
1
51.7
hemoglobin measurement
1
1
1
40.5
refractive error measurement
1
1
0
5.8
18.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
73.3
creatine kinase measurement
1
52.2
body mass index
1
51.7
hemoglobin measurement
1
40.5
refractive error measurement
0
5.8
18.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BTB domain and CNC homolog 1
VGNC:7161
745234
Macaque
BTB domain and CNC homolog 1
705817
Mouse
MGI:894680
12013
Rat
RGD:1306693
304127
Dog
BTB domain and CNC homolog 1
VGNC:38360
487718
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BTB domain and CNC homolog 1
Macaque
BTB domain and CNC homolog 1
Mouse
Rat
Dog
BTB domain and CNC homolog 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14867-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (53)
1 – 10 of 53
CREB5
Tbio
Family: TF
Novelty: 0.03857106
p_int: 0.999999998
p_ni: 2e-9
Score: 0.738
Data Source: BioPlex,STRINGDB
MAFF
Tbio
Family: TF
Novelty: 0.01974936
p_int: 0.999999997
p_ni: 3e-9
Score: 0.605
Data Source: BioPlex,STRINGDB
HMMR
Tbio
Novelty: 0.0039196
p_int: 0.999999951
p_ni: 4.4e-8
p_wrong: 5e-9
Score: 0.562
Data Source: BioPlex,STRINGDB
ZBTB24
Tbio
Family: TF
Novelty: 0.041401
p_int: 0.999998622
p_ni: 0.000001378
Data Source: BioPlex
FAM83D
Tbio
Novelty: 0.07381559
p_int: 0.999998602
p_ni: 0.000001398
Score: 0.203
Data Source: BioPlex,STRINGDB
POTEKP
Tdark
p_int: 0.999997569
p_ni: 0.00000243
Data Source: BioPlex
BATF3
Tbio
Family: TF
Novelty: 0.01554987
p_int: 0.999996282
p_ni: 0.000003708
p_wrong: 1e-8
Score: 0.216
Data Source: BioPlex,STRINGDB
ATP23
Tbio
Family: Enzyme
Novelty: 0.09823059
p_int: 0.999995982
p_ni: 0.000003974
p_wrong: 4.4e-8
Score: 0.159
Data Source: BioPlex,STRINGDB
CREBZF
Tbio
Family: TF
Novelty: 0.06925638
p_int: 0.999987673
p_ni: 0.00001228
p_wrong: 4.7e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
KIF2B
Tbio
Novelty: 0.09958244
p_int: 0.999980753
p_ni: 0.000019246
Data Source: BioPlex
Publication Statistics
PubMed Score  13.17

PubMed score by year
PubTator Score  111.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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