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Tbio
SLC30A4
Zinc transporter 4

Protein Summary
Description
Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment. Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261867
  • ENSP00000261867
  • ENSG00000104154

Symbol
  • ZNT4
  • ZNT4
  • znT-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
histone modification site profile
0.71
tissue sample
0.71
cellular component
0.68
disease perturbation
0.68


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.8   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.8   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
4
6
98.2
creatinine measurement
3
3
4
92.6
urinary albumin to creatinine ratio
2
2
2
70.2
1
1
0
1.1
66.8
urinary potassium to creatinine ratio
1
1
1
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
98.2
creatinine measurement
4
92.6
urinary albumin to creatinine ratio
2
70.2
0
1.1
66.8
urinary potassium to creatinine ratio
1
59.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 4
VGNC:13424
453403
Macaque
solute carrier family 30 member 4
713510
Mouse
MGI:1345282
22785
Rat
RGD:619750
64469
Dog
solute carrier family 30 member 4
VGNC:46349
487539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 4
Macaque
solute carrier family 30 member 4
Mouse
Rat
Dog
solute carrier family 30 member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14863-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Zinc homeostasis
WikiPathways
Zinc homeostasis
WikiPathways
Zinc homeostasis
Name
Explore in Pharos
Explore in Source
Zinc homeostasis
Zinc homeostasis
Zinc homeostasis
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (66)
1 – 10 of 66
PDS5B
Tbio
Novelty:  0.00295057
p_int:  0.999817968
p_ni:  0.000182031
p_wrong:  1e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
RBM25
Tbio
Novelty:  0.05557892
p_int:  0.999250705
p_ni:  0.000749295
Score:  0.213
Data Source:  BioPlex,STRINGDB
PRPF40A
Tbio
Novelty:  0.00898047
p_int:  0.997916892
p_ni:  0.002083107
p_wrong:  1e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.965835186
p_ni:  0.034164814
Data Source:  BioPlex
PDS5A
Tbio
Novelty:  0.0142948
p_int:  0.965294643
p_ni:  0.034705357
Score:  0.183
Data Source:  BioPlex,STRINGDB
C19orf25
Tdark
Novelty:  8.61479932
p_int:  0.953918431
p_ni:  0.046076507
p_wrong:  0.000005062
Score:  0.167
Data Source:  BioPlex,STRINGDB
EIF5
Tbio
Novelty:  0.00897488
p_int:  0.925292082
p_ni:  0.074707918
Score:  0.288
Data Source:  BioPlex,STRINGDB
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.888121662
p_ni:  0.111152765
p_wrong:  0.000725572
Data Source:  BioPlex
NCAM1
Tbio
Novelty:  0.00020994
p_int:  0.834527915
p_ni:  0.165472085
Score:  0.183
Data Source:  BioPlex,STRINGDB
MLST8
Tbio
Novelty:  0.00423122
p_int:  0.799568054
p_ni:  0.200431946
Score:  0.173
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  43.80

PubMed score by year
PubTator Score  25.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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