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Tchem
FFAR1
Free fatty acid receptor 1

Protein Summary
Description
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246553
  • ENSP00000246553
  • ENSG00000126266

Symbol
  • GPR40
  • FFA1R
  • GPR40
  • GPCR40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
biological process
0.65
tissue
0.64
ligand (chemical)
0.61
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.78   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.78   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 272
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
rosiglitazone
chemical structure image
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Reactome
Free fatty acid receptors
Reactome
Free fatty acids regulate insulin secretion
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Free fatty acid receptors
Free fatty acids regulate insulin secretion
G alpha (q) signalling events
Protein-Protein Interactions (193)
1 – 10 of 193
FFAR4
Tchem
Family: GPCR
Novelty: 0.00439747
Score: 0.992
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.966
Data Source: STRINGDB
GPRC6A
Tchem
Family: GPCR
Novelty: 0.01625616
Score: 0.957
Data Source: STRINGDB
GIP
Tchem
Novelty: 0.0007219
Score: 0.955
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.954
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.95
Data Source: STRINGDB
AVPR1B
Tclin
Family: GPCR
Novelty: 0.00774309
Score: 0.942
Data Source: STRINGDB
CASR
Tclin
Family: GPCR
Novelty: 0.00061316
Score: 0.941
Data Source: STRINGDB
GPR39
Tchem
Family: GPCR
Novelty: 0.01244607
Score: 0.926
Data Source: STRINGDB
GCGR
Tclin
Family: GPCR
Novelty: 0.00392059
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  433.78

PubMed score by year
PubTator Score  206.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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