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Tbio
OPLAH
5-oxoprolinase

Protein Classes
Protein Summary
Description
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618853
  • ENSP00000480476
  • ENSG00000178814

Symbol
  • OPLA
  • OPLAHD
  • 5-Opase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
co-expressed gene
0.69
histone modification site profile
0.69
PubMedID
0.68
cell type or tissue
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.79   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.79   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
7
10
96.4
mean corpuscular volume
2
2
2
90.4
blood metabolite measurement
1
2
2
89.7
total cholesterol measurement
3
3
3
87.9
apolipoprotein B measurement
2
2
2
87.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
10
96.4
mean corpuscular volume
2
90.4
blood metabolite measurement
2
89.7
total cholesterol measurement
3
87.9
apolipoprotein B measurement
2
87.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1922725
75475
Rat
RGD:620956
116684
Dog
5-oxoprolinase, ATP-hydrolysing
VGNC:49607
482085
Cow
5-oxoprolinase, ATP-hydrolysing
VGNC:53869
408006
Pig
5-oxoprolinase, ATP-hydrolysing
100515137
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
5-oxoprolinase, ATP-hydrolysing
Cow
5-oxoprolinase, ATP-hydrolysing
Pig
5-oxoprolinase, ATP-hydrolysing
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14841-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Glutathione conjugation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Disease
Diseases of metabolism
Glutathione conjugation
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (42)
1 – 10 of 42
GGCT
Tchem
Family:  Enzyme
Novelty:  0.01154389
Score:  0.992
Data Source:  STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
Score:  0.954
Data Source:  STRINGDB
GGT5
Tbio
Family:  Enzyme
Novelty:  0.00602505
Score:  0.947
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.94
Data Source:  STRINGDB
GGT6
Tbio
Family:  Enzyme
Novelty:  0.016069
Score:  0.937
Data Source:  STRINGDB
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
Score:  0.91
Data Source:  STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
Score:  0.909
Data Source:  STRINGDB
GLUD1
Tbio
Family:  Enzyme
Novelty:  0.00301109
Score:  0.835
Data Source:  STRINGDB
GLUD2
Tbio
Family:  Enzyme
Novelty:  0.01470266
Score:  0.83
Data Source:  STRINGDB
GLS2
Tchem
Family:  Enzyme
Novelty:  0.00284878
Score:  0.826
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.79

PubMed score by year
PubTator Score  33.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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