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Tbio
PHYH
Phytanoyl-CoA dioxygenase, peroxisomal

Protein Summary
Description
Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. This gene is a member of the PhyH family and encodes a peroxisomal protein that is involved in the alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Mutations in this gene have been associated with Refsum disease (RD) and deficient protein activity has been associated with Zellweger syndrome and rhizomelic chondrodysplasia punctata. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263038
  • ENSP00000263038
  • ENSG00000107537
  • ENST00000396913
  • ENSP00000380121

Symbol
  • PAHX
  • RD
  • LN1
  • PAHX
  • LNAP1
  • PHYH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.98
transcription factor perturbation
0.98
molecular function
0.76
cellular component
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.9   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.9   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phytanoyl-CoA 2-hydroxylase
VGNC:7248
450310
Macaque
phytanoyl-CoA 2-hydroxylase
695915
Mouse
MGI:891978
16922
Rat
RGD:620317
114209
Dog
phytanoyl-CoA hydroxylase-like
478000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phytanoyl-CoA 2-hydroxylase
Macaque
phytanoyl-CoA 2-hydroxylase
Mouse
Rat
Dog
phytanoyl-CoA hydroxylase-like
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14832-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Alpha-oxidation of phytanate (R-HSA-389599)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alpha-oxidation of phytanate
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Alpha-oxidation of phytanate
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Protein-Protein Interactions (79)
1 – 10 of 79
C6orf226
Tdark
Novelty: 4.2303719
p_int: 0.999999876
p_ni: 1.24e-7
Score: 0.68
Data Source: BioPlex,STRINGDB
PEX7
Tbio
Novelty: 0.01487923
Score: 0.984
Data Source: Reactome,STRINGDB
ACAA1
Tbio
Family: Enzyme
Novelty: 0.00710465
Score: 0.973
Data Source: STRINGDB
PEX14
Tbio
Novelty: 0.0210557
Score: 0.96
Data Source: Reactome,STRINGDB
HACL1
Tbio
Family: Enzyme
Novelty: 0.05302548
Score: 0.955
Data Source: STRINGDB
SLC27A2
Tbio
Family: Transporter
Novelty: 0.01436035
Score: 0.95
Data Source: STRINGDB
AGPS
Tbio
Family: Enzyme
Novelty: 0.01075549
Score: 0.948
Data Source: STRINGDB
TYSND1
Tbio
Family: Enzyme
Novelty: 0.16036122
Score: 0.942
Data Source: Reactome,STRINGDB
PEX2
Tbio
Novelty: 0.01015599
Score: 0.938
Data Source: Reactome,STRINGDB
PEX13
Tbio
Novelty: 0.01777214
Score: 0.937
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  362.90

PubMed score by year
PubTator Score  123.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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