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Tbio
PPEF1
Serine/threonine-protein phosphatase with EF-hands 1

Protein Summary
Description
May have a role in the recovery or adaptation response of photoreceptors. May have a role in development. This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349874
  • ENSP00000341892
  • ENSG00000086717
  • ENST00000361511
  • ENSP00000354871

Symbol
  • PPEF
  • PPP7C
  • PP7
  • PPEF
  • PPP7C
  • PPP7CA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.6
tissue sample
0.57
transcription factor
0.55
cell line
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.01   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.01   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase with EF-hand domain 1
VGNC:10179
107966472
Macaque
protein phosphatase with EF-hand domain 1
694108
Mouse
MGI:1097157
237178
Rat
RGD:1562772
317498
Dog
protein phosphatase with EF-hand domain 1
VGNC:44842
100688966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase with EF-hand domain 1
Macaque
protein phosphatase with EF-hand domain 1
Mouse
Rat
Dog
protein phosphatase with EF-hand domain 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14829-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (39)
1 – 10 of 39
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.811459448
p_ni: 0.188540552
Score: 0.232
Data Source: BioPlex,STRINGDB
RHO
Tbio
Family: GPCR
Novelty: 0.00012925
Score: 0.962
Data Source: Reactome,STRINGDB
SCML2
Tbio
Family: Epigenetic
Novelty: 0.04486535
Score: 0.807
Data Source: STRINGDB
GOLPH3
Tbio
Novelty: 0.00020234
Score: 0.744
Data Source: STRINGDB
PTPA
Tchem
Family: Enzyme
Novelty: 0.00048652
Score: 0.706
Data Source: STRINGDB
CDKL5
Tchem
Family: Kinase
Novelty: 0.00444062
Score: 0.686
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.638
Data Source: STRINGDB
ENDOU
Tbio
Family: Enzyme
Novelty: 0.01074988
Score: 0.586
Data Source: STRINGDB
PPP1R8
Tbio
Family: Enzyme
Novelty: 0.00138054
Score: 0.55
Data Source: STRINGDB
PPP2R1B
Tbio
Family: Enzyme
Novelty: 0.03936638
Score: 0.548
Data Source: STRINGDB
Publication Statistics
PubMed Score  196.01

PubMed score by year
PubTator Score  46.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer