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Tbio
RASGRF2
Ras-specific guanine nucleotide-releasing factor 2

Protein Summary
Description
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265080
  • ENSP00000265080
  • ENSG00000113319

Symbol
  • GRF2
  • GRF2
  • RAS-GRF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.75
PubMedID
0.63
histone modification site profile
0.61
phenotype
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.11   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.11   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.963
Data Source:  Reactome,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.947
Data Source:  Reactome,STRINGDB
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
Score:  0.947
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.945
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.945
Data Source:  STRINGDB
CAMK2A
Tchem
Family:  Kinase
Novelty:  0.00534906
Score:  0.943
Data Source:  Reactome,STRINGDB
GRIN2B
Tclin
Family:  IC
Novelty:  0.00035058
Score:  0.942
Data Source:  Reactome,STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.933
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.929
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets (16)
Explore Nearest Tclin Targets
1 – 5 of 12
CALM1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  1
CALM2
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  1
CALM3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  1
CACNA1C
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA2D1
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (147)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cell death signalling via NRAGE, NRIF and NADE
Cytokine Signaling in Immune system
Death Receptor Signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
94.8
risk-taking behaviour
3
4
5
84.5
smoking status measurement
2
2
2
71.1
smoking behavior
1
1
1
33.1
alcohol consumption measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
94.8
risk-taking behaviour
5
84.5
smoking status measurement
2
71.1
smoking behavior
1
33.1
alcohol consumption measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras protein specific guanine nucleotide releasing factor 2
VGNC:4143
461771
Mouse
MGI:109137
19418
Dog
Ras protein specific guanine nucleotide releasing factor 2
VGNC:45371
610203
Horse
Ras protein specific guanine nucleotide releasing factor 2
VGNC:22200
100073254
Cow
Ras protein specific guanine nucleotide releasing factor 2
VGNC:33746
524957
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras protein specific guanine nucleotide releasing factor 2
Mouse
Dog
Ras protein specific guanine nucleotide releasing factor 2
Horse
Ras protein specific guanine nucleotide releasing factor 2
Cow
Ras protein specific guanine nucleotide releasing factor 2
Publication Statistics
PubMed Score 43.11
PubMed score by year
PubTator Score 18.41
PubTator score by year
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Related Publications
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PMID
Year
Title