Tbio CPLX1 Complexin-1

Protein Summary

Description

Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14810
• A6NI80
• B2R4R5
• D3DVN3
• F1T0G1

Gene Name

• CPLX1

Ensembl ID

• ENST00000304062
• ENSP00000305613
• ENSG00000168993

Symbol

• CPX1
• CPX-I
• EIEE63

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.87
tissue	0.62
transcription factor perturbation	0.61
gene perturbation	0.59
PubMedID	0.59

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.77   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.77   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (11)

Reactome (9)

KEGG (1)

WikiPathways (1)

Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

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Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Acetylcholine Neurotransmitter Release Cycle	17 targets	R-HSA-264642
Reactome	Dopamine Neurotransmitter Release Cycle	23 targets	R-HSA-212676
Reactome	GABA synthesis, release, reuptake and degradation	19 targets	R-HSA-888590
Reactome	Glutamate Neurotransmitter Release Cycle	24 targets	R-HSA-210500
Reactome	Neuronal System	398 targets	R-HSA-112316

Name	Explore in Pharos	Explore in Source
Acetylcholine Neurotransmitter Release Cycle	17 targets	R-HSA-264642
Dopamine Neurotransmitter Release Cycle	23 targets	R-HSA-212676
GABA synthesis, release, reuptake and degradation	19 targets	R-HSA-888590
Glutamate Neurotransmitter Release Cycle	24 targets	R-HSA-210500
Neuronal System	398 targets	R-HSA-112316

Gene Ontology Terms (22)

Functions (3)

Components (11)

Processes (8)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
SNARE binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neurotransmitter transporter activity	Inferred from Electronic Annotation (IEA)	Ensembl
syntaxin-1 binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (165)

Explore Interacting Targets

1 – 10 of 165

• See Interactions on String-DB

CPLX2

Tbio

Novelty: 0.01904583

p_int: 0.999999976

p_ni: 2.4e-8

Score: 0.898

Data Source: BioPlex,STRINGDB

VAMP3

Tbio

Novelty: 0.00974462

p_int: 0.922868393

p_ni: 0.077131347

p_wrong: 2.6e-7

Score: 0.841

Data Source: BioPlex,STRINGDB

GYPB

Tbio

Novelty: 0.00257625

p_int: 0.810195139

p_ni: 0.189750613

p_wrong: 0.000054248

Score: 0.173

Data Source: BioPlex,STRINGDB

SYT1

Tbio

Novelty: 0.00202951

Score: 0.998

Data Source: STRINGDB

SNAP25

Tclin

Novelty: 0.0020914

Score: 0.998

Data Source: STRINGDB

STX1A

Tbio

Novelty: 0.00128938

Score: 0.996

Data Source: STRINGDB

VAMP2

Tbio

Novelty: 0.00274235

Score: 0.988

Data Source: STRINGDB

RAB3A

Tbio

Family: Enzyme

Novelty: 0.00506015

Score: 0.97

Data Source: STRINGDB

SYT2

Tbio

Novelty: 0.01076581

Score: 0.969

Data Source: STRINGDB

SYN2

Tbio

Novelty: 0.00508386

Score: 0.968

Data Source: STRINGDB

Publication Statistics

PubMed Score  88.77

PubMed score by year

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PubTator Score  41.32

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKY

1-70

GIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK

70-134

MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK

Find similar targets by:

Uniprot Keyword

3D-structure
Coiled coil
Complete proteome
Cytoplasm
Disease mutation
Epilepsy
Exocytosis
Neurotransmitter transport
Reference proteome
Transport