Protein Summary
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
- ENST00000304062
- ENSP00000305613
- ENSG00000168993
- CPX1
- CPX-I
- EIEE63
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.87 | ||
tissue | 0.62 | ||
transcription factor perturbation | 0.61 | ||
gene perturbation | 0.59 | ||
PubMedID | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.52 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 158 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.52 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 158 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (165)
CPLX2
Novelty: 0.01821493
p_int: 0.999999976
p_ni: 2.4e-8
Score: 0.898
Data Source: BioPlex,STRINGDB
VAMP3
Novelty: 0.00694332
p_int: 0.922868393
p_ni: 0.077131347
p_wrong: 2.6e-7
Score: 0.841
Data Source: BioPlex,STRINGDB
GYPB
Novelty: 0.00442195
p_int: 0.810195139
p_ni: 0.189750613
p_wrong: 0.000054248
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (9)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acetylcholine Neurotransmitter Release Cycle | ||||
Reactome | Dopamine Neurotransmitter Release Cycle | ||||
Reactome | GABA synthesis, release, reuptake and degradation | ||||
Reactome | Glutamate Neurotransmitter Release Cycle | ||||
Reactome | Neuronal System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acetylcholine Neurotransmitter Release Cycle | ||||
Dopamine Neurotransmitter Release Cycle | ||||
GABA synthesis, release, reuptake and degradation | ||||
Glutamate Neurotransmitter Release Cycle | ||||
Neuronal System | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (3)
Components (11)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 2 | 3 | 90.3 | |||||
myeloid white cell count | 2 | 2 | 2 | 89.7 | |||||
monocyte percentage of leukocytes | 2 | 2 | 2 | 89.5 | |||||
leukocyte count | 2 | 2 | 2 | 86.2 | |||||
3 | 2 | 2 | 1.1 | 83.4 | |||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 90.3 | |||||
myeloid white cell count | 2 | 89.7 | |||||
monocyte percentage of leukocytes | 2 | 89.5 | |||||
leukocyte count | 2 | 86.2 | |||||
2 | 1.1 | 83.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | complexin 1 | 703519 | ||||||
Mouse | MGI:104727 | 12889 | ||||||
Rat | RGD:70944 | 64832 | ||||||
Dog | complexin 1 | VGNC:39555 | 479134 | |||||
Horse | complexin 1 | VGNC:16817 | 100050943 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | complexin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | complexin 1 | |||||
Horse | complexin 1 | |||||
Publication Statistics
PubMed Score 73.52
PubMed score by year
PubTator Score 41.32
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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