You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MRAS
Ras-related protein M-Ras

Protein Summary
Description
May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway. This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289104
  • ENSP00000289104
  • ENSG00000158186
  • ENST00000423968
  • ENSP00000389682
  • ENST00000464896
  • ENSP00000419582
  • ENST00000474559
  • ENSP00000418356
  • ENST00000614350
  • ENSP00000484586
  • ENST00000621127
  • ENSP00000481637

Symbol
  • RRAS3
  • M-RAs
  • RRAS3
  • R-RAS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
PubMedID
0.86
gene perturbation
0.73
virus perturbation
0.72
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.82   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.82   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
p_int:  0.999817905
p_ni:  0.000182083
p_wrong:  1.3e-8
Score:  0.686
Data Source:  BioPlex,STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.975
Data Source:  STRINGDB
RAPGEF5
Tbio
Novelty:  0.02449802
Score:  0.965
Data Source:  STRINGDB
SHOC2
Tbio
Novelty:  0.01203957
Score:  0.962
Data Source:  STRINGDB
AFDN
Tbio
Novelty:  0.00372947
Score:  0.962
Data Source:  STRINGDB
RALGDS
Tbio
Novelty:  0.00362484
Score:  0.943
Data Source:  STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.942
Data Source:  STRINGDB
RAPGEF2
Tbio
Novelty:  0.03353183
Score:  0.937
Data Source:  STRINGDB
RAPGEF6
Tbio
Novelty:  0.07979293
Score:  0.932
Data Source:  STRINGDB
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (123)
Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Autophagy - animal
KEGG
Regulation of actin cytoskeleton
KEGG
Mitophagy - animal
KEGG
C-type lectin receptor signaling pathway
KEGG
Apelin signaling pathway
Name
Explore in Pharos
Explore in Source
Autophagy - animal
Regulation of actin cytoskeleton
Mitophagy - animal
C-type lectin receptor signaling pathway
Apelin signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
4
1.1
91.1
waist circumference
1
3
3
84.6
BMI-adjusted waist-hip ratio
2
4
4
83.2
waist-hip ratio
1
3
3
81.6
mathematical ability
3
3
5
76.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
91.1
waist circumference
3
84.6
BMI-adjusted waist-hip ratio
4
83.2
waist-hip ratio
3
81.6
mathematical ability
5
76.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
muscle RAS oncogene homolog
VGNC:10042
470938
Macaque
muscle RAS oncogene homolog
716352
Mouse
MGI:1100856
17532
Rat
RGD:3111
25482
Dog
muscle RAS oncogene homolog
VGNC:43358
477082
Species
Name
OMA
EggNOG
Inparanoid
Chimp
muscle RAS oncogene homolog
Macaque
muscle RAS oncogene homolog
Mouse
Rat
Dog
muscle RAS oncogene homolog
Publication Statistics
PubMed Score 75.82
PubMed score by year
PubTator Score 20.64
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title