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Tchem
TAAR5
Trace amine-associated receptor 5

Protein Summary
Description
Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258034
  • ENSP00000258034
  • ENSG00000135569

Symbol
  • PNR
  • PNR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.52
tissue
0.46
cell line
0.43
chemical
0.42
gene perturbation
0.42


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trace amine associated receptor 5
VGNC:3719
472128
Macaque
trace amine associated receptor 5
709325
Mouse
MGI:2685073
215854
Rat
RGD:1359185
294123
Dog
trace amine associated receptor 5
VGNC:47059
483989
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trace amine associated receptor 5
Macaque
trace amine associated receptor 5
Mouse
Rat
Dog
trace amine associated receptor 5
Pathways (12)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (140)
1 – 10 of 140
SCT
Tbio
Novelty: 0.00070278
Score: 0.923
Data Source: STRINGDB
GPR27
Tbio
Family: GPCR
Novelty: 0.164488
Score: 0.923
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.922
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.919
Data Source: STRINGDB
DRD5
Tchem
Family: GPCR
Novelty: 0.00803909
Score: 0.919
Data Source: STRINGDB
GPR150
Tdark
Family: GPCR
Novelty: 0.91287003
Score: 0.917
Data Source: STRINGDB
DRD1
Tclin
Family: GPCR
Novelty: 0.00165886
Score: 0.916
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.916
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.916
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.51

PubMed score by year
PubTator Score  52.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer