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Tbio
POLR3A
DNA-directed RNA polymerase III subunit RPC1

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372371
  • ENSP00000361446
  • ENSG00000148606

Symbol
  • ADDH
  • HLD7
  • RPC1
  • WDRTS
  • RPC155
  • hRPC155
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
protein domain
0.92
molecular function
0.81
cell line
0.66
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.04   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.04   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (327)
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
p_int:  0.999981498
p_ni:  0.000018502
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR3GL
Tdark
Family:  Enzyme
Novelty:  0.35648533
p_int:  0.999975223
p_ni:  0.000024777
Score:  0.98
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  0.999944862
p_ni:  0.000055138
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.999925635
p_ni:  0.000074365
Score:  0.998
Data Source:  BioPlex,STRINGDB
UXT
Tbio
Novelty:  0.0272609
p_int:  0.999857221
p_ni:  0.000142779
Score:  0.832
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.999572413
p_ni:  0.000427587
Score:  0.68
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999494617
p_ni:  0.000505383
Score:  0.61
Data Source:  BioPlex,STRINGDB
POLR3E
Tbio
Family:  Enzyme
Novelty:  0.06500715
p_int:  0.999121356
p_ni:  0.000878644
Score:  0.999
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.998953477
p_ni:  0.001046523
Score:  0.346
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.998287617
p_ni:  0.001712383
Score:  0.736
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
7
7
3.5
99.4
serum alanine aminotransferase measurement
3
3
2
10.8
94.2
alkaline phosphatase measurement
2
1
1
8.2
81.1
aspartate aminotransferase measurement
1
1
1
70.2
appendicular lean mass
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
7
3.5
99.4
serum alanine aminotransferase measurement
2
10.8
94.2
alkaline phosphatase measurement
1
8.2
81.1
aspartate aminotransferase measurement
1
70.2
appendicular lean mass
1
1.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit A
VGNC:8884
450543
Macaque
RNA polymerase III subunit A
100424410
Mouse
MGI:2681836
218832
Rat
RGD:1305574
361102
Dog
RNA polymerase III subunit A
VGNC:44800
479256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit A
Macaque
RNA polymerase III subunit A
Mouse
Rat
Dog
RNA polymerase III subunit A
Publication Statistics
PubMed Score 75.04
PubMed score by year
PubTator Score 62.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title