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Tbio
APOL1
Apolipoprotein L1

Protein Summary
Description
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319136
  • ENSP00000317674
  • ENSG00000100342
  • ENST00000397278
  • ENSP00000380448
  • ENST00000397279
  • ENSP00000380449
  • ENST00000422706
  • ENSP00000411507
  • ENST00000426053
  • ENSP00000388477

Symbol
  • APOL
  • APOL
  • APO-L
  • FSGS4
  • APOL-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
tissue sample
0.75
cell type or tissue
0.73
molecular function
0.63
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 718.45   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 718.45   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
APOA1
Tbio
Novelty:  0.0001216
Score:  0.982
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.949
Data Source:  STRINGDB
APOA2
Tbio
Novelty:  0.00117627
Score:  0.949
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.942
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.937
Data Source:  STRINGDB
SERPINA1
Tbio
Novelty:  0.00014098
Score:  0.934
Data Source:  STRINGDB
CST3
Tbio
Novelty:  0.00021856
Score:  0.932
Data Source:  STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.927
Data Source:  STRINGDB
APOA5
Tbio
Novelty:  0.00232222
Score:  0.927
Data Source:  STRINGDB
HBB
Tbio
Novelty:  0.00049683
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
90.1
mean corpuscular volume
1
2
2
88.6
heel bone mineral density
2
2
2
79.5
alkaline phosphatase measurement
1
1
1
77.3
2
2
0
2.2
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
90.1
mean corpuscular volume
2
88.6
heel bone mineral density
2
79.5
alkaline phosphatase measurement
1
77.3
0
2.2
74.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 718.45
PubMed score by year
PubTator Score 341.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title