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Tchem
NRP1
Neuropilin-1

Protein Summary
Description
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel numbe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265371
  • ENSP00000265371
  • ENSG00000099250
  • ENST00000374821
  • ENSP00000363954
  • ENST00000374822
  • ENSP00000363955
  • ENST00000374867
  • ENSP00000364001

Symbol
  • NRP
  • VEGF165R
  • NP1
  • NRP
  • BDCA4
  • CD304
  • VEGF165R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein complex
1
transcription factor perturbation
1
gene perturbation
0.99
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 570.45   (req: < 5)
Gene RIFs: 219   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 570.45   (req: >= 5)
Gene RIFs: 219   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 94
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
EG01377
chemical structure image
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CHL1 interactions
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
CHL1 interactions
CRMPs in Sema3A signaling
Developmental Biology
L1CAM interactions
Gene Ontology Terms (111)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (192)
1 – 10 of 192
KCTD9
Tbio
Novelty: 0.30071599
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
BCS1L
Tbio
Family: Enzyme
Novelty: 0.00258512
p_int: 0.999999721
p_ni: 2.79e-7
Data Source: BioPlex
ODF2
Tbio
Novelty: 0.03275361
p_int: 0.999901227
p_ni: 0.000012282
p_wrong: 0.000086491
Score: 0.19
Data Source: BioPlex,STRINGDB
FAM241A
Tdark
Novelty: 2.7184466
p_int: 0.999164276
p_ni: 0.000835688
p_wrong: 3.6e-8
Data Source: BioPlex
TNFAIP1
Tbio
Novelty: 0.04871082
p_int: 0.998269354
p_ni: 0.001720834
p_wrong: 0.000009811
Score: 0.313
Data Source: BioPlex,STRINGDB
TMX1
Tbio
Novelty: 0.01558923
p_int: 0.997279754
p_ni: 0.002720246
Data Source: BioPlex
UBR2
Tbio
Family: Enzyme
Novelty: 0.03319944
p_int: 0.99315068
p_ni: 0.00684932
Data Source: BioPlex
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00124949
p_int: 0.9900044
p_ni: 0.0099956
Score: 0.231
Data Source: BioPlex,STRINGDB
UBR1
Tbio
Family: Enzyme
Novelty: 0.00742688
p_int: 0.988982702
p_ni: 0.011017298
Data Source: BioPlex
PIP5K1A
Tbio
Family: Kinase
Novelty: 0.08213456
p_int: 0.988472897
p_ni: 0.011527102
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  570.45

PubMed score by year
PubTator Score  652.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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