Protein Summary
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel numbe ...more
- ENST00000265371
- ENSP00000265371
- ENSG00000099250
- ENST00000374821
- ENSP00000363954
- ENST00000374822
- ENSP00000363955
- ENST00000374867
- ENSP00000364001
- NRP
- VEGF165R
- NP1
- NRP
- BDCA4
- CD304
- VEGF165R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
protein complex | 1 | ||
transcription factor perturbation | 1 | ||
gene perturbation | 0.99 | ||
protein domain | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 777.57 (req: < 5)
Gene RIFs: 219 (req: <= 3)
Antibodies: 810 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 777.57 (req: >= 5)
Gene RIFs: 219 (req: > 3)
Antibodies: 810 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 94
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (6)
Protein-Protein Interactions (192)
KCTD9
Novelty: 0.22841768
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
ODF2
Novelty: 0.03203587
p_int: 0.999901227
p_ni: 0.000012282
p_wrong: 0.000086491
Score: 0.19
Data Source: BioPlex,STRINGDB
FAM241A
Novelty: 1.04041354
p_int: 0.999164276
p_ni: 0.000835688
p_wrong: 3.6e-8
Data Source: BioPlex
TNFAIP1
Novelty: 0.04006419
p_int: 0.998269354
p_ni: 0.001720834
p_wrong: 0.000009811
Score: 0.313
Data Source: BioPlex,STRINGDB
CSNK2A1
Family: Kinase
Novelty: 0.00187855
p_int: 0.9900044
p_ni: 0.0099956
Score: 0.231
Data Source: BioPlex,STRINGDB
UBR1
Family: Enzyme
Novelty: 0.00998888
p_int: 0.988982702
p_ni: 0.011017298
Data Source: BioPlex
PIP5K1A
Family: Kinase
Novelty: 0.05039085
p_int: 0.988472897
p_ni: 0.011527102
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (20)
Reactome (14)
KEGG (2)
PathwayCommons (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | CHL1 interactions | ||||
Reactome | CRMPs in Sema3A signaling | ||||
Reactome | Developmental Biology | ||||
Reactome | L1CAM interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
CHL1 interactions | ||||
CRMPs in Sema3A signaling | ||||
Developmental Biology | ||||
L1CAM interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (111)
Functions (10)
Components (17)
Processes (84)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 1 | 2 | 2 | 64.8 | |||||
waist-hip ratio | 3 | 4 | 4 | 60.2 | |||||
biological sex | 1 | 1 | 1 | 48.5 | |||||
BMI-adjusted waist-hip ratio | 1 | 2 | 2 | 37.3 | |||||
1 | 1 | 0 | 1.1 | 33.1 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 2 | 64.8 | |||||
waist-hip ratio | 4 | 60.2 | |||||
biological sex | 1 | 48.5 | |||||
BMI-adjusted waist-hip ratio | 2 | 37.3 | |||||
0 | 1.1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | neuropilin 1 | VGNC:4969 | 450397 | |||||
Macaque | neuropilin 1 | 697755 | ||||||
Mouse | MGI:106206 | 18186 | ||||||
Rat | RGD:621588 | 246331 | ||||||
Dog | neuropilin 1 | VGNC:43974 | 477955 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | neuropilin 1 | |||||
Macaque | neuropilin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuropilin 1 | |||||
Publication Statistics
PubMed Score 777.57
PubMed score by year
PubTator Score 652.88
PubTator score by year
Related Publications
Text Mined References (265)
GeneRif Annotations (219)
Items per page:
0 of 0
PMID | Year | Title |
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