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Tchem
NRP1
Neuropilin-1

Protein Summary
Description
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel numbe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265371
  • ENSP00000265371
  • ENSG00000099250
  • ENST00000374821
  • ENSP00000363954
  • ENST00000374822
  • ENSP00000363955
  • ENST00000374867
  • ENSP00000364001

Symbol
  • NRP
  • VEGF165R
  • NP1
  • NRP
  • BDCA4
  • CD304
  • VEGF165R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein complex
1
transcription factor perturbation
1
gene perturbation
0.99
protein domain
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 777.57   (req: < 5)
Gene RIFs: 219   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 777.57   (req: >= 5)
Gene RIFs: 219   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 94
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
2
2
64.8
waist-hip ratio
3
4
4
60.2
biological sex
1
1
1
48.5
BMI-adjusted waist-hip ratio
1
2
2
37.3
1
1
0
1.1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
64.8
waist-hip ratio
4
60.2
biological sex
1
48.5
BMI-adjusted waist-hip ratio
2
37.3
0
1.1
33.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropilin 1
VGNC:4969
450397
Macaque
neuropilin 1
697755
Mouse
MGI:106206
18186
Rat
RGD:621588
246331
Dog
neuropilin 1
VGNC:43974
477955
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropilin 1
Macaque
neuropilin 1
Mouse
Rat
Dog
neuropilin 1
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14786-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CHL1 interactions
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
CHL1 interactions
CRMPs in Sema3A signaling
Developmental Biology
L1CAM interactions
Gene Ontology Terms (111)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (192)
1 – 10 of 192
KCTD9
Tbio
Novelty:  0.22841768
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
BCS1L
Tbio
Family:  Enzyme
Novelty:  0.01764582
p_int:  0.999999721
p_ni:  2.79e-7
Data Source:  BioPlex
ODF2
Tbio
Novelty:  0.03203587
p_int:  0.999901227
p_ni:  0.000012282
p_wrong:  0.000086491
Score:  0.19
Data Source:  BioPlex,STRINGDB
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.999164276
p_ni:  0.000835688
p_wrong:  3.6e-8
Data Source:  BioPlex
TNFAIP1
Tbio
Novelty:  0.04006419
p_int:  0.998269354
p_ni:  0.001720834
p_wrong:  0.000009811
Score:  0.313
Data Source:  BioPlex,STRINGDB
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.997279754
p_ni:  0.002720246
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.99315068
p_ni:  0.00684932
Data Source:  BioPlex
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.9900044
p_ni:  0.0099956
Score:  0.231
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.988982702
p_ni:  0.011017298
Data Source:  BioPlex
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
p_int:  0.988472897
p_ni:  0.011527102
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  777.57

PubMed score by year
PubTator Score  652.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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