Tbio KIF3C Kinesin-like protein KIF3C

Protein Summary

Description

Microtubule-based anterograde translocator for membranous organelles.

Uniprot Accession IDs

• O14782
• O43544
• Q4ZG18
• Q53SX5
• Q562F7

Gene Name

• KIF3C

Ensembl ID

• ENST00000264712
• ENSP00000264712
• ENSG00000084731
• ENST00000405914
• ENSP00000385030

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
disease perturbation	0.96
kinase perturbation	0.88
tissue sample	0.72
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif3c

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif3c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.04   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.04   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (190)

Explore Interacting Targets

1 – 10 of 190

• See Interactions on String-DB

KIFAP3

Tbio

Novelty:  0.01902437

p_int:  0.999999952

p_ni:  2e-9

p_wrong:  4.7e-8

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

KIF3A

Tbio

Novelty:  0.00555124

p_int:  0.999998872

p_ni:  0.000001123

p_wrong:  5e-9

Score:  0.976

Data Source:  BioPlex,Reactome,STRINGDB

KIF1BP

Tbio

Novelty:  0.03932922

p_int:  0.999990747

p_ni:  0.000009197

p_wrong:  5.6e-8

Score:  0.745

Data Source:  BioPlex,STRINGDB

IFT57

Tbio

Novelty:  0.03373199

Score:  0.972

Data Source:  STRINGDB

IFT20

Tbio

Novelty:  0.03005088

Score:  0.965

Data Source:  Reactome,STRINGDB

IFT52

Tbio

Novelty:  0.04183122

Score:  0.959

Data Source:  STRINGDB

IFT88

Tbio

Novelty:  0.00727114

Score:  0.954

Data Source:  STRINGDB

KLC1

Tbio

Novelty:  0.00653484

Score:  0.947

Data Source:  STRINGDB

KLC2

Tbio

Novelty:  0.06284367

Score:  0.945

Data Source:  STRINGDB

DYNC2LI1

Tbio

Novelty:  0.05087433

Score:  0.945

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (14)

Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets

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5

1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Golgi-to-ER retrograde transport	117 targets	R-HSA-8856688

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Cilium Assembly	187 targets	R-HSA-5617833
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Golgi-to-ER retrograde transport	117 targets	R-HSA-8856688

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (5)

Components (5)

Processes (5)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
ATPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
microtubule binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
microtubule motor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
motor activity	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2	2	2		90
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		82.7
atrial fibrillation	EFO_0000275	2	2	0	1.1	72.8
hemoglobin measurement	EFO_0004509	1	1	1		69.2
heel bone mineral density	EFO_0009270	2	3	4		68.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2		90
mean corpuscular hemoglobin concentration	EFO_0004528	1		82.7
atrial fibrillation	EFO_0000275	0	1.1	72.8
hemoglobin measurement	EFO_0004509	1		69.2
heel bone mineral density	EFO_0009270	4		68.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Microtubule
Motor protein
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
atrial fibrillation
Cough
heel bone mineral density
hemoglobin measurement
mean corpuscular hemoglobin concentration
myeloid white cell count
response to angiotensin-converting enzyme inhibitor
reticulocyte measurement
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	kinesin family member 3C	VGNC:283	459078
Macaque	kinesin family member 3C		695287
Mouse	kinesin family member 3C	MGI:107979	16570
Rat	kinesin family member 3C	RGD:621538	85248
Dog	kinesin family member 3C	VGNC:42406	482999

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kinesin family member 3C
Macaque	kinesin family member 3C
Mouse	kinesin family member 3C
Rat	kinesin family member 3C
Dog	kinesin family member 3C

Publication Statistics

PubMed Score 22.04

PubMed score by year

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PubTator Score 6.11

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (3)

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10

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PMID	Year	Title