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Tbio
KIF3C
Kinesin-like protein KIF3C

Protein Summary
Description
Microtubule-based anterograde translocator for membranous organelles.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264712
  • ENSP00000264712
  • ENSG00000084731
  • ENST00000405914
  • ENSP00000385030
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease perturbation
0.96
kinase perturbation
0.88
tissue sample
0.72
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.04   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.04   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (190)
KIFAP3
Tbio
Novelty:  0.01902437
p_int:  0.999999952
p_ni:  2e-9
p_wrong:  4.7e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.999998872
p_ni:  0.000001123
p_wrong:  5e-9
Score:  0.976
Data Source:  BioPlex,Reactome,STRINGDB
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.999990747
p_ni:  0.000009197
p_wrong:  5.6e-8
Score:  0.745
Data Source:  BioPlex,STRINGDB
IFT57
Tbio
Novelty:  0.03373199
Score:  0.972
Data Source:  STRINGDB
IFT20
Tbio
Novelty:  0.03005088
Score:  0.965
Data Source:  Reactome,STRINGDB
IFT52
Tbio
Novelty:  0.04183122
Score:  0.959
Data Source:  STRINGDB
IFT88
Tbio
Novelty:  0.00727114
Score:  0.954
Data Source:  STRINGDB
KLC1
Tbio
Novelty:  0.00653484
Score:  0.947
Data Source:  STRINGDB
KLC2
Tbio
Novelty:  0.06284367
Score:  0.945
Data Source:  STRINGDB
DYNC2LI1
Tbio
Novelty:  0.05087433
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cilium Assembly
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Cilium Assembly
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
90
mean corpuscular hemoglobin concentration
1
1
1
82.7
2
2
0
1.1
72.8
hemoglobin measurement
1
1
1
69.2
heel bone mineral density
2
3
4
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
90
mean corpuscular hemoglobin concentration
1
82.7
0
1.1
72.8
hemoglobin measurement
1
69.2
heel bone mineral density
4
68.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 3C
VGNC:283
459078
Macaque
kinesin family member 3C
695287
Mouse
MGI:107979
16570
Rat
RGD:621538
85248
Dog
kinesin family member 3C
VGNC:42406
482999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 3C
Macaque
kinesin family member 3C
Mouse
Rat
Dog
kinesin family member 3C
Publication Statistics
PubMed Score 22.04
PubMed score by year
PubTator Score 6.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title