Tbio NDC80 Kinetochore protein NDC80 homolog

Protein Summary

Description

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108). This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• O14777
• Q6PJX2

Gene Name

• NDC80

Ensembl ID

• ENST00000261597
• ENSP00000261597
• ENSG00000080986

Symbol

• HEC
• HEC1
• KNTC2
• HEC
• HEC1
• TID3
• KNTC2
• HsHec1
• hsNDC80

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.97
interacting protein	0.89
histone modification site profile	0.85
gene perturbation	0.83
cellular component	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Kinetochore Protein Ndc80 Homolog

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Kinetochore Protein Ndc80 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.85   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 405   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.85   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0