TCERG1
Transcription elongation regulator 1
Protein Summary
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000296702
- ENSP00000296702
- ENSG00000113649
- ENST00000394421
- ENSP00000377943
- CA150
- TAF2S
- Urn1
- CA150
- TAF2S
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.92 | ||
disease perturbation | 0.9 | ||
transcription factor binding site profile | 0.9 | ||
interacting protein | 0.85 | ||
molecular function | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.91 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 172 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.91 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 172 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (141)
CBWD1
Novelty: 0.04321511
p_int: 0.987294181
p_ni: 0.012705819
Score: 0.665
Data Source: BioPlex,STRINGDB
CBWD2
Novelty: 5.35433071
p_int: 0.822639632
p_ni: 0.177360368
Score: 0.855
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Spliceosome | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Spliceosome | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (7)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 30.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 0.9 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 1 | 30.2 | |||||
self reported educational attainment | 1 | 0.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transcription elongation regulator 1 | VGNC:4190 | 462168 | |||||
Macaque | transcription elongation regulator 1 | 707912 | ||||||
Mouse | MGI:1926421 | 56070 | ||||||
Rat | RGD:1311748 | 307474 | ||||||
Dog | transcription elongation regulator 1 | VGNC:47188 | 478052 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transcription elongation regulator 1 | |||||
Macaque | transcription elongation regulator 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transcription elongation regulator 1 | |||||
Publication Statistics
PubMed Score 57.91
PubMed score by year
PubTator Score 30.66
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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