You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TCERG1
Transcription elongation regulator 1

Protein Summary
Description
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296702
  • ENSP00000296702
  • ENSG00000113649
  • ENST00000394421
  • ENSP00000377943

Symbol
  • CA150
  • TAF2S
  • Urn1
  • CA150
  • TAF2S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
disease perturbation
0.9
transcription factor binding site profile
0.9
interacting protein
0.85
molecular function
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.9   (req: < 5)
View Publications
Gene RIFs: 20   (req: <= 3)
View Gene RIFs
Antibodies: 172   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.9   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription elongation regulator 1
VGNC:4190
462168
Macaque
transcription elongation regulator 1
707912
Mouse
transcription elongation regulator 1 (CA150)
MGI:1926421
56070
Rat
transcription elongation regulator 1
RGD:1311748
307474
Dog
transcription elongation regulator 1
VGNC:47188
478052
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription elongation regulator 1
Macaque
transcription elongation regulator 1
Mouse
transcription elongation regulator 1 (CA150)
Rat
transcription elongation regulator 1
Dog
transcription elongation regulator 1
Protein Structure (23 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14776-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
transcription corepressor activity
Inferred from Direct Assay (IDA)
BHF-UCL
identical protein binding
Inferred from Physical Interaction (IPI)
IntAct
RNA polymerase II repressing transcription factor binding
Inferred from Physical Interaction (IPI)
BHF-UCL
RNA binding
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
RNA polymerase binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
transcription coactivator activity
Traceable Author Statement (TAS)
ProtInc
proline-rich region binding
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (141)
1 – 10 of 141
CBWD1
Tbio
Novelty: 0.04321511
p_int: 0.987294181
p_ni: 0.012705819
Score: 0.665
Data Source: BioPlex,STRINGDB
CBWD2
Tdark
Novelty: 5.35433071
p_int: 0.822639632
p_ni: 0.177360368
Score: 0.855
Data Source: BioPlex,STRINGDB
SF3B4
Tbio
Novelty: 0.0197008
Score: 0.978
Data Source: STRINGDB
SF3B1
Tbio
Novelty: 0.0128965
Score: 0.973
Data Source: STRINGDB
SF3A1
Tbio
Novelty: 0.03405702
Score: 0.971
Data Source: STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
Score: 0.959
Data Source: STRINGDB
SF3A3
Tbio
Novelty: 0.03815499
Score: 0.959
Data Source: STRINGDB
SF3B2
Tbio
Novelty: 0.0271365
Score: 0.952
Data Source: STRINGDB
SNRPA1
Tbio
Novelty: 0.01232044
Score: 0.951
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.90

PubMed score by year
PubTator Score  30.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer