Tbio GNB5 Guanine nucleotide-binding protein subunit beta-5

Protein Summary

Description

Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14775
• B2RBR5
• Q9HAU9
• Q9UFT3

Gene Name

• GNB5

Ensembl ID

• ENST00000261837
• ENSP00000261837
• ENSG00000069966
• ENST00000358784
• ENSP00000351635
• ENST00000396335
• ENSP00000379626

Symbol

• GB5
• IDDCA
• LADCI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
protein domain	0.92
transcription factor perturbation	0.84
pathway	0.77
microRNA	0.72

Protein Classes

PANTHER Classes

Protein / Hydrolase / Guanine Nucleotide-binding Protein Subunit Beta-5

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein Subunit Beta-5

DTO Classes

Protein / Enzyme / Hydrolase / Guanine Nucleotide-binding Protein Subunit Beta-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.96   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 282   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.96   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0