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Tbio
GNB5
Guanine nucleotide-binding protein subunit beta-5

Protein Summary
Description
Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261837
  • ENSP00000261837
  • ENSG00000069966
  • ENST00000358784
  • ENSP00000351635
  • ENST00000396335
  • ENSP00000379626

Symbol
  • GB5
  • IDDCA
  • LADCI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
protein domain
0.92
transcription factor perturbation
0.84
pathway
0.77
microRNA
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.4   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.4   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (121)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 53
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of kainate receptors upon glutamate binding
Adrenaline,noradrenaline inhibits insulin secretion
Aquaporin-mediated transport
Protein-Protein Interactions (598)
1 – 10 of 598
RGS6
Tbio
Novelty: 0.02200804
p_int: 0.999999971
p_ni: 2.4e-8
p_wrong: 5e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
RGS7
Tbio
Novelty: 0.01643407
p_int: 0.999998375
p_ni: 5.08e-7
p_wrong: 0.000001117
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RGS9
Tbio
Novelty: 0.06662559
p_int: 0.999995945
p_ni: 0.000004055
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
GNG2
Tbio
Novelty: 0.04807242
p_int: 0.999991378
p_ni: 0.000008622
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
PRPF40B
Tdark
Novelty: 0.04278291
p_int: 0.999973653
p_ni: 0.000026337
p_wrong: 1e-8
Score: 0.825
Data Source: BioPlex,STRINGDB
PDCL
Tbio
Novelty: 0.00317454
p_int: 0.999950183
p_ni: 0.000049817
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.891809865
p_ni: 0.108190135
Score: 0.919
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.879036925
p_ni: 0.120963075
Score: 0.91
Data Source: BioPlex,STRINGDB
COPS5
Tbio
Novelty: 0.00406225
p_int: 0.877340394
p_ni: 0.122659606
Data Source: BioPlex
CCT7
Tbio
Novelty: 0.02247038
p_int: 0.791071591
p_ni: 0.208928409
Score: 0.93
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  153.40

PubMed score by year
PubTator Score  51.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer