Tbio TPP1 Tripeptidyl-peptidase 1

Protein Summary

Description

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14773
• Q53HT1
• Q5JAK6
• Q6UX56
• Q71JP6
• Q96C37
• TPP-1

Gene Name

• TPP1

Ensembl ID

• ENST00000299427
• ENSP00000299427
• ENSG00000166340
• ENST00000533371
• ENSP00000437066
• ENST00000642892
• ENSP00000494165
• ENST00000645620
• ENSP00000493657
• ENST00000647152
• ENSP00000495893

Symbol

• CLN2
• CLN2
• GIG1
• LPIC
• SCAR7
• TPP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.96
interacting protein	0.9
small molecule perturbation	0.86
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Tripeptidyl-peptidase 1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Tripeptidyl-peptidase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.08   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 384   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.08   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0