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Tbio
TPP1
Tripeptidyl-peptidase 1

Protein Summary
Description
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299427
  • ENSP00000299427
  • ENSG00000166340
  • ENST00000533371
  • ENSP00000437066
  • ENST00000642892
  • ENSP00000494165
  • ENST00000645620
  • ENSP00000493657
  • ENST00000647152
  • ENSP00000495893

Symbol
  • CLN2
  • CLN2
  • GIG1
  • LPIC
  • SCAR7
  • TPP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.96
interacting protein
0.9
small molecule perturbation
0.86
transcription factor perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.9   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.9   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripeptidyl peptidase 1
VGNC:10187
450999
Macaque
tripeptidyl peptidase 1
709838
Mouse
MGI:1336194
12751
Rat
RGD:621296
83534
Dog
tripeptidyl peptidase 1
VGNC:47747
485337
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripeptidyl peptidase 1
Macaque
tripeptidyl peptidase 1
Mouse
Rat
Dog
tripeptidyl peptidase 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14773-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (47)
1 – 10 of 47
OMA1
Tbio
Family: Enzyme
Novelty: 0.00963387
p_int: 0.990018224
p_ni: 0.009981776
Score: 0.292
Data Source: BioPlex,STRINGDB
DGKG
Tbio
Family: Enzyme
Novelty: 0.03666646
p_int: 0.988578064
p_ni: 0.011421936
Data Source: BioPlex
NME4
Tbio
Family: Kinase
Novelty: 0.03735196
p_int: 0.919763387
p_ni: 0.080236613
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC25A16
Tbio
Family: Transporter
Novelty: 0.00778831
p_int: 0.904525331
p_ni: 0.095474669
Score: 0.237
Data Source: BioPlex,STRINGDB
RPTOR
Tbio
Novelty: 0.00119147
p_int: 0.896087802
p_ni: 0.103912198
Score: 0.188
Data Source: BioPlex,STRINGDB
CLN5
Tbio
Novelty: 0.01124343
Score: 0.827
Data Source: STRINGDB
TINF2
Tbio
Novelty: 0.0064505
Score: 0.816
Data Source: STRINGDB
CLN6
Tbio
Novelty: 0.01095683
Score: 0.789
Data Source: STRINGDB
MFSD8
Tbio
Novelty: 0.03388459
Score: 0.786
Data Source: STRINGDB
TERF1
Tbio
Family: TF
Novelty: 0.00174529
Score: 0.778
Data Source: STRINGDB
Publication Statistics
PubMed Score  175.90

PubMed score by year
PubTator Score  264.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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