TPP1
Tripeptidyl-peptidase 1
Protein Classes
Protein Summary
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
- ENST00000299427
- ENSP00000299427
- ENSG00000166340
- ENST00000533371
- ENSP00000437066
- ENST00000642892
- ENSP00000494165
- ENST00000645620
- ENSP00000493657
- ENST00000647152
- ENSP00000495893
- CLN2
- CLN2
- GIG1
- LPIC
- SCAR7
- TPP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.96 | ||
interacting protein | 0.9 | ||
small molecule perturbation | 0.86 | ||
transcription factor perturbation | 0.84 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 175.9 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 384 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 175.9 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 384 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tripeptidyl peptidase 1 | VGNC:10187 | 450999 | |||||
Macaque | tripeptidyl peptidase 1 | 709838 | ||||||
Mouse | MGI:1336194 | 12751 | ||||||
Rat | RGD:621296 | 83534 | ||||||
Dog | tripeptidyl peptidase 1 | VGNC:47747 | 485337 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tripeptidyl peptidase 1 | |||||
Macaque | tripeptidyl peptidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tripeptidyl peptidase 1 | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | IRE1alpha activates chaperones | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Unfolded Protein Response (UPR) | ||||
Reactome | XBP1(S) activates chaperone genes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
IRE1alpha activates chaperones | ||||
Metabolism of proteins | ||||
Unfolded Protein Response (UPR) | ||||
XBP1(S) activates chaperone genes | ||||
Gene Ontology Terms (21)
Functions (7)
Components (4)
Processes (10)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (47)
1 – 10 of 47
OMA1
Family: Enzyme
Novelty: 0.00963387
p_int: 0.990018224
p_ni: 0.009981776
Score: 0.292
Data Source: BioPlex,STRINGDB
DGKG
Family: Enzyme
Novelty: 0.03666646
p_int: 0.988578064
p_ni: 0.011421936
Data Source: BioPlex
NME4
Family: Kinase
Novelty: 0.03735196
p_int: 0.919763387
p_ni: 0.080236613
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC25A16
Family: Transporter
Novelty: 0.00778831
p_int: 0.904525331
p_ni: 0.095474669
Score: 0.237
Data Source: BioPlex,STRINGDB
RPTOR
Novelty: 0.00119147
p_int: 0.896087802
p_ni: 0.103912198
Score: 0.188
Data Source: BioPlex,STRINGDB
CLN5
Novelty: 0.01124343
Score: 0.827
Data Source: STRINGDB
TINF2
Novelty: 0.0064505
Score: 0.816
Data Source: STRINGDB
CLN6
Novelty: 0.01095683
Score: 0.789
Data Source: STRINGDB
MFSD8
Novelty: 0.03388459
Score: 0.786
Data Source: STRINGDB
TERF1
Family: TF
Novelty: 0.00174529
Score: 0.778
Data Source: STRINGDB
Publication Statistics
PubMed Score 175.90
PubMed score by year
PubTator Score 264.53
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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