TPP1
Tripeptidyl-peptidase 1
Protein Classes
Protein Summary
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
- ENST00000299427
- ENSP00000299427
- ENSG00000166340
- ENST00000533371
- ENSP00000437066
- ENST00000642892
- ENSP00000494165
- ENST00000645620
- ENSP00000493657
- ENST00000647152
- ENSP00000495893
- CLN2
- CLN2
- GIG1
- LPIC
- SCAR7
- TPP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.96 | ||
interacting protein | 0.9 | ||
small molecule perturbation | 0.86 | ||
transcription factor perturbation | 0.84 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.65 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 384 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.65 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 384 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | IRE1alpha activates chaperones | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Unfolded Protein Response (UPR) | ||||
Reactome | XBP1(S) activates chaperone genes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
IRE1alpha activates chaperones | ||||
Metabolism of proteins | ||||
Unfolded Protein Response (UPR) | ||||
XBP1(S) activates chaperone genes | ||||
Gene Ontology Terms (21)
Functions (7)
Components (4)
Processes (10)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (47)
1 – 10 of 47
OMA1
Family: Enzyme
Novelty: 0.01481124
p_int: 0.990018224
p_ni: 0.009981776
Score: 0.292
Data Source: BioPlex,STRINGDB
DGKG
Family: Enzyme
Novelty: 0.04706767
p_int: 0.988578064
p_ni: 0.011421936
Data Source: BioPlex
NME4
Family: Kinase
Novelty: 0.01754371
p_int: 0.919763387
p_ni: 0.080236613
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC25A16
Family: Transporter
Novelty: 0.00123354
p_int: 0.904525331
p_ni: 0.095474669
Score: 0.237
Data Source: BioPlex,STRINGDB
RPTOR
Novelty: 0.00128955
p_int: 0.896087802
p_ni: 0.103912198
Score: 0.188
Data Source: BioPlex,STRINGDB
CLN5
Novelty: 0.01318345
Score: 0.827
Data Source: STRINGDB
TINF2
Novelty: 0.00842437
Score: 0.816
Data Source: STRINGDB
CLN6
Novelty: 0.01237641
Score: 0.789
Data Source: STRINGDB
MFSD8
Novelty: 0.01280168
Score: 0.786
Data Source: STRINGDB
TERF1
Family: TF
Novelty: 0.00225772
Score: 0.778
Data Source: STRINGDB
Publication Statistics
PubMed Score 158.65
PubMed score by year
PubTator Score 264.53
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSD
1-70
PSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHH
70-140
YVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYN
140-210
LTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYL
210-280
MSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAAR
280-350
GLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPS
350-420
YQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINE
420-490
HRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTL
490-560
LNP
560-563
MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
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