Tbio TPP1 Tripeptidyl-peptidase 1

Protein Summary

Description

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14773
• Q53HT1
• Q5JAK6
• Q6UX56
• Q71JP6
• Q96C37
• TPP-1

Gene Name

• TPP1

Ensembl ID

• ENST00000299427
• ENSP00000299427
• ENSG00000166340
• ENST00000533371
• ENSP00000437066
• ENST00000642892
• ENSP00000494165
• ENST00000645620
• ENSP00000493657
• ENST00000647152
• ENSP00000495893

Symbol

• CLN2
• CLN2
• GIG1
• LPIC
• SCAR7
• TPP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.96
interacting protein	0.9
small molecule perturbation	0.86
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Tripeptidyl-peptidase 1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Tripeptidyl-peptidase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.68   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 384   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.68   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (47)

Explore Interacting Targets

1 – 10 of 47

• See Interactions on String-DB

OMA1

Tbio

Family:  Enzyme

Novelty:  0.00963387

p_int:  0.990018224

p_ni:  0.009981776

Score:  0.292

Data Source:  BioPlex,STRINGDB

DGKG

Tbio

Family:  Enzyme

Novelty:  0.03666646

p_int:  0.988578064

p_ni:  0.011421936

Data Source:  BioPlex

NME4

Tbio

Family:  Kinase

Novelty:  0.03735196

p_int:  0.919763387

p_ni:  0.080236613

Score:  0.187

Data Source:  BioPlex,STRINGDB

SLC25A16

Tbio

Family:  Transporter

Novelty:  0.00778831

p_int:  0.904525331

p_ni:  0.095474669

Score:  0.237

Data Source:  BioPlex,STRINGDB

RPTOR

Tbio

Novelty:  0.00119147

p_int:  0.896087802

p_ni:  0.103912198

Score:  0.188

Data Source:  BioPlex,STRINGDB

CLN5

Tbio

Novelty:  0.01124343

Score:  0.827

Data Source:  STRINGDB

TINF2

Tbio

Novelty:  0.0064505

Score:  0.816

Data Source:  STRINGDB

CLN6

Tbio

Novelty:  0.01095683

Score:  0.789

Data Source:  STRINGDB

MFSD8

Tbio

Novelty:  0.03388459

Score:  0.786

Data Source:  STRINGDB

TERF1

Tbio

Family:  TF

Novelty:  0.00174529

Score:  0.778

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

IRE1alpha activates chaperones (R-HSA-381070)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	IRE1alpha activates chaperones	50 targets	R-HSA-381070
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Unfolded Protein Response (UPR)	92 targets	R-HSA-381119
Reactome	XBP1(S) activates chaperone genes	48 targets	R-HSA-381038

Name	Explore in Pharos	Explore in Source
IRE1alpha activates chaperones	50 targets	R-HSA-381070
Metabolism of proteins	2050 targets	R-HSA-392499
Unfolded Protein Response (UPR)	92 targets	R-HSA-381119
XBP1(S) activates chaperone genes	48 targets	R-HSA-381038

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (7)

Components (4)

Processes (10)

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1 – 7 of 7

GO Term	Evidence	Assigned by
endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
tripeptidyl-peptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
peptidase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
serine-type peptidase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
peptide binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
serine-type endopeptidase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	2	2	2		57.7
platelet crit	EFO_0007985	1	1	1		40.7
mammographic density measurement	EFO_0005941	1	1	1		1.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	2		57.7
platelet crit	EFO_0007985	1		40.7
mammographic density measurement	EFO_0005941	1		1.8

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UniProt Keyword Find Similar Targets

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3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein

GWAS Trait Find Similar Targets

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hemoglobin measurement
mammographic density measurement
platelet crit

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cellular phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
muscle phenotype
nervous system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tripeptidyl peptidase 1	VGNC:10187	450999
Macaque	tripeptidyl peptidase 1		709838
Mouse	tripeptidyl peptidase I	MGI:1336194	12751
Rat	tripeptidyl peptidase 1	RGD:621296	83534
Dog	tripeptidyl peptidase 1	VGNC:47747	485337

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tripeptidyl peptidase 1
Macaque	tripeptidyl peptidase 1
Mouse	tripeptidyl peptidase I
Rat	tripeptidyl peptidase 1
Dog	tripeptidyl peptidase 1

Publication Statistics

PubMed Score 197.68

PubMed score by year

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PubTator Score 264.53

PubTator score by year

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Related Publications

Text Mined References (78)

GeneRif Annotations (45)

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10

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PMID	Year	Title