TPP1
Tripeptidyl-peptidase 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.96 | ||
interacting protein | 0.9 | ||
small molecule perturbation | 0.86 | ||
transcription factor perturbation | 0.84 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | IRE1alpha activates chaperones | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Unfolded Protein Response (UPR) | ||||
Reactome | XBP1(S) activates chaperone genes | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
IRE1alpha activates chaperones | ||||
Metabolism of proteins | ||||
Unfolded Protein Response (UPR) | ||||
XBP1(S) activates chaperone genes | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 2 | 2 | 2 | 57.7 | |||||
platelet crit | 1 | 1 | 1 | 40.7 | |||||
mammographic density measurement | 1 | 1 | 1 | 1.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hemoglobin measurement | 2 | 57.7 | |||||
platelet crit | 1 | 40.7 | |||||
mammographic density measurement | 1 | 1.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tripeptidyl peptidase 1 | VGNC:10187 | 450999 | |||||
Macaque | tripeptidyl peptidase 1 | 709838 | ||||||
Mouse | MGI:1336194 | 12751 | ||||||
Rat | RGD:621296 | 83534 | ||||||
Dog | tripeptidyl peptidase 1 | VGNC:47747 | 485337 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tripeptidyl peptidase 1 | |||||
Macaque | tripeptidyl peptidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tripeptidyl peptidase 1 | |||||
PMID | Year | Title |
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